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Julia Bode
German Cancer Research Center
PathologyIn vivoGliomaCancer researchBiology
10Publications
6H-index
91Citations
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Publications 14
Newest
#1Artur Hahn (Heidelberg University)H-Index: 2
#2Julia Bode (DKFZ: German Cancer Research Center)H-Index: 6
Last. Sabine Heiland (Heidelberg University)H-Index: 45
view all 14 authors...
Abstract Microvascular proliferation in glioblastoma multiforme is a biological key mechanism to facilitate tumor growth and infiltration and a main target for treatment interventions. The vascular architecture can be obtained by Single Plane Illumination Microscopy (SPIM) to evaluate vascular heterogeneity in tumorous tissue. We make use of the Gibbs point field model to quantify the order of regularity in capillary distributions found in the U87 glioblastoma model in a murine model and to comp...
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#1Artur Hahn (Heidelberg University)H-Index: 2
#2Julia Bode (DKFZ: German Cancer Research Center)H-Index: 6
Last. Martin Bendszus (University Hospital Heidelberg)H-Index: 62
view all 13 authors...
Remodeling of tissue microvasculature commonly promotes neoplastic growth; however, there is no imaging modality in oncology yet that noninvasively quantifies microvascular changes in clinical routine. Although blood capillaries cannot be resolved in typical magnetic resonance imaging (MRI) measurements, their geometry and distribution influence the integral nuclear magnetic resonance (NMR) signal from each macroscopic MRI voxel. We have numerically simulated the expected transverse relaxation i...
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#1Himanshu Soni (DKFZ: German Cancer Research Center)H-Index: 1
#2Julia Bode (DKFZ: German Cancer Research Center)H-Index: 6
Last. Betty A. Eipper (University of Connecticut Health Center)H-Index: 65
view all 12 authors...
PKR-like kinase (PERK) plays a significant role in inducing angiogenesis in various cancer types including glioblastoma. By proteomics analysis of the conditioned medium from a glioblastoma cell line treated with a PERK inhibitor, we showed that peptidylglycine α-amidating monooxygenase (PAM) expression is regulated by PERK under hypoxic conditions. Moreover, PERK activation via CCT020312 (a PERK selective activator) increased the cleavage and thus the generation of PAM cleaved cytosolic domain ...
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#1Artur Hahn (Heidelberg University)H-Index: 2
#2Julia Bode (DKFZ: German Cancer Research Center)H-Index: 6
Last. Felix T. Kurz (Heidelberg University)H-Index: 13
view all 10 authors...
Glioblastoma multiforme alters healthy tissue vasculature by inducing angiogenesis and vascular remodeling. To fully comprehend the structural and functional properties of the resulting vascular network, it needs to be studied collectively by considering both geometric and topological properties. Utilizing Single Plane Illumination Microscopy (SPIM), the detailed capillary structure in entire healthy and tumor-bearing mouse brains could be resolved in three dimensions. At the scale of the smalle...
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#1Peter Wirthschaft (DKFZ: German Cancer Research Center)H-Index: 1
#2Julia Bode (DKFZ: German Cancer Research Center)H-Index: 6
Last. Björn Tews (DKFZ: German Cancer Research Center)H-Index: 9
view all 23 authors...
Glioblastomas strongly invade the brain by infiltrating into the white matter along myelinated nerve fiber tracts even though the myelin protein Nogo-A prevents cell migration by activating inhibitory RhoA signaling. The mechanisms behind this long-known phenomenon remained elusive so far, precluding a targeted therapeutic intervention. This study demonstrates that the prevalent activation of AKT in gliomas increases the ER protein-folding capacity and enables tumor cells to utilize a side effec...
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#1Michael O. Breckwoldt (DKFZ: German Cancer Research Center)H-Index: 11
#2Julia Bode (DKFZ: German Cancer Research Center)H-Index: 6
Last. Björn Tews (DKFZ: German Cancer Research Center)H-Index: 9
view all 19 authors...
Diffuse tumor infiltration into the adjacent parenchyma is an effective dissemination mechanism of brain tumors. We have previously developed correlated high field magnetic resonance imaging and ultramicroscopy (MR-UM) to study neonangiogenesis in a glioma model. In the present study we used MR-UM to investigate tumor infiltration and neoangiogenesis in a translational approach. We compare infiltration and neoangiogenesis patterns in four brain tumor models and the human disease: whereas the U87...
2 CitationsSource
#1Peter Wirthschaft (DKFZ: German Cancer Research Center)H-Index: 1
#2Julia Bode (DKFZ: German Cancer Research Center)H-Index: 6
Last. Björn Tews (DKFZ: German Cancer Research Center)H-Index: 9
view all 25 authors...
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#1Fernanda Ramos-Gomes (MPG: Max Planck Society)H-Index: 2
#2Julia Bode (MPG: Max Planck Society)H-Index: 6
Last. Frauke Alves (MPG: Max Planck Society)H-Index: 31
view all 14 authors...
Early detection of malignant tumours and, especially, micrometastases and disseminated tumour cells is still a challenge. In order to implement highly sensitive diagnostic tools we demonstrate the use of nanoprobes engineered from nanobodies (single-domain antibodies, sdAbs) and fluorescent quantum dots (QDs) for single-and two-photon detection and imaging of human micrometastases and disseminated tumour cells in ex vivo biological samples of breast and pancreatic metastatic tumour mouse models ...
8 CitationsSource
#1Klara Kirschbaum (DKFZ: German Cancer Research Center)H-Index: 2
#2Jana K. Sonner (DKFZ: German Cancer Research Center)H-Index: 6
Last. Michael O. Breckwoldt (DKFZ: German Cancer Research Center)H-Index: 11
view all 18 authors...
Abstract Innate immune cells play a key role in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). Current clinical imaging is restricted to visualizing secondary effects of inflammation, such as gliosis and blood–brain barrier disruption. Advanced molecular imaging, such as iron oxide nanoparticle imaging, can allow direct imaging of cellular and molecular activity, but the exact cell types that phagocytose nanoparticles in vivo and how phagocytic activi...
26 CitationsSource
#1Sandro Alves (University of Paris-Sud)H-Index: 6
#2Julia Bode (DKFZ: German Cancer Research Center)H-Index: 6
Last. Björn Tews (DKFZ: German Cancer Research Center)H-Index: 9
view all 6 authors...
Viral vectors enable a controlled spatiotemporal expression of transgenes of interest in several tissues and have become a widely used vehicle for gene transfer in biological sciences, including neurobiology1. In the last few years, recombinant viral vectors derived from adeno-associated virus (AAV) have evolved as an important and reliable tool for gene transfer2. AAVs are very small non-enveloped single-stranded DNA viruses with a tiny capsid (~22 nm). AAVs belong to the family of Parvoviridae...
8 CitationsSource
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