Original paper

Selective separation method of aggregates from IgG solution by aqueous two-phase system

Volume: 161, Pages: 57 - 62
Published: Sep 1, 2019
Abstract
Aggregation of immunoglobulin G (IgG) is a serious concern that results in immunogenicity in pharmaceutical applications. Removal of the small and soluble aggregates in protein solutions through a simple method remains challenging. Here we show that an aqueous two-phase system (ATPS) can be used for the elimination of soluble aggregates from IgG solution. Polyethylene glycol (PEG) and dextran (DEX) were selected as components of the ATPS. As...
Paper Details
Title
Selective separation method of aggregates from IgG solution by aqueous two-phase system
Published Date
Sep 1, 2019
Volume
161
Pages
57 - 62
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