O2.3. INCREASED PROTEIN INSOLUBILITY IN BRAINS FROM A SUBSET OF PATIENTS WITH SCHIZOPHRENIA

The mechanisms leading to schizophrenia are likely to be diverse. However, there may be common pathophysiological pathways for subsets of the disease. In the present study, we hypothesized that disruption of protein quality control can lead to protein insolubility for a subset of patients with schizophrenia. Prefrontal cortex or superior temporal gyrus from autopsy brains provided by the University of Pittsburgh, University of Texas...