Physical inactivity, cardiometabolic disease, and risk of dementia: an individual-participant meta-analysis

Objective To examine whether physical inactivity is a risk factor for dementia, with attention to the role of cardiometabolic disease in this association and reverse causation bias that arises from changes in physical activity in the preclinical (prodromal) phase of dementia. Design Meta-analysis of 19 prospective observational cohort studies. Data sources The Individual-Participant-Data Meta-analysis in Working Populations Consortium, the...