Original paper

IL-38 Ameliorates Skin Inflammation and Limits IL-17 Production from γδ T Cells

Volume: 27, Issue: 3, Pages: 835 - 846.e5
Published: Apr 1, 2019
Abstract
Interleukin-38 (IL-38) is a cytokine of the IL-1 family with a role in chronic inflammation. However, its main cellular targets and receptors remain obscure. IL-38 is highly expressed in the skin and downregulated in psoriasis patients. We report an investigation in cellular targets of IL-38 during the progression of imiquimod-induced psoriasis. In this model, IL-38 knockout (IL-38 KO) mice show delayed disease resolution with exacerbated...
Paper Details
Title
IL-38 Ameliorates Skin Inflammation and Limits IL-17 Production from γδ T Cells
Published Date
Apr 1, 2019
Volume
27
Issue
3
Pages
835 - 846.e5
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