Match!

Ancient genomes indicate population replacement in Early Neolithic Britain

Published on May 1, 2019in Nature Ecology and Evolution10.965
· DOI :10.1038/s41559-019-0871-9
Selina Brace12
Estimated H-index: 12
(Natural History Museum),
Yoan Diekmann10
Estimated H-index: 10
(UCL: University College London)
+ 24 AuthorsIan Barnes37
Estimated H-index: 37
(Natural History Museum)
Abstract
The roles of migration, admixture and acculturation in the European transition to farming have been debated for over 100 years. Genome-wide ancient DNA studies indicate predominantly Aegean ancestry for continental Neolithic farmers, but also variable admixture with local Mesolithic hunter-gatherers. Neolithic cultures first appear in Britain circa 4000 bc, a millennium after they appeared in adjacent areas of continental Europe. The pattern and process of this delayed British Neolithic transition remain unclear. We assembled genome-wide data from 6 Mesolithic and 67 Neolithic individuals found in Britain, dating 8500–2500 bc. Our analyses reveal persistent genetic affinities between Mesolithic British and Western European hunter-gatherers. We find overwhelming support for agriculture being introduced to Britain by incoming continental farmers, with small, geographically structured levels of hunter-gatherer ancestry. Unlike other European Neolithic populations, we detect no resurgence of hunter-gatherer ancestry at any time during the Neolithic in Britain. Genetic affinities with Iberian Neolithic individuals indicate that British Neolithic people were mostly descended from Aegean farmers who followed the Mediterranean route of dispersal. We also infer considerable variation in pigmentation levels in Europe by circa 6000 bc.
  • References (51)
  • Citations (7)
📖 Papers frequently viewed together
21 Authors (Selina Brace, ..., Ian Barnes)
6 Citations
9 Citations
43 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References51
Newest
#1Juan Camilo Chacón-Duque (UCL: University College London)H-Index: 7
#2Kaustubh Adhikari (UCL: University College London)H-Index: 11
Last. Andres Ruiz-Linares (AMU: Aix-Marseille University)H-Index: 43
view all 50 authors...
Historical records and genetic analyses indicate that Latin Americans trace their ancestry mainly to the intermixing (admixture) of Native Americans, Europeans and Sub-Saharan Africans. Using novel haplotype-based methods, here we infer sub-continental ancestry in over 6,500 Latin Americans and evaluate the impact of regional ancestry variation on physical appearance. We find that Native American ancestry components in Latin Americans correspond geographically to the present-day genetic structur...
18 CitationsSource
#1Lakshmi Chaitanya (EUR: Erasmus University Rotterdam)H-Index: 10
#2Krystal Breslin (IUPUI: Indiana University – Purdue University Indianapolis)H-Index: 4
Last. Susan Walsh (IUPUI: Indiana University – Purdue University Indianapolis)H-Index: 16
view all 12 authors...
Abstract Forensic DNA Phenotyping (FDP), i.e. the prediction of human externally visible traits from DNA, has become a fast growing subfield within forensic genetics due to the intelligence information it can provide from DNA traces. FDP outcomes can help focus police investigations in search of unknown perpetrators, who are generally unidentifiable with standard DNA profiling. Therefore, we previously developed and forensically validated the IrisPlex DNA test system for eye colour prediction an...
26 CitationsSource
#1Arwin Ralf (EUR: Erasmus University Rotterdam)H-Index: 13
#2Diego Montiel González (EUR: Erasmus University Rotterdam)H-Index: 1
Last. Manfred Kayser (EUR: Erasmus University Rotterdam)H-Index: 71
view all 4 authors...
4 CitationsSource
#1Iñigo Olalde (Harvard University)H-Index: 13
#2Selina Brace (Natural History Museum)H-Index: 12
Last. David Reich (HHMI: Howard Hughes Medical Institute)H-Index: 109
view all 144 authors...
From around 2750 to 2500 bc, Bell Beaker pottery became widespread across western and central Europe, before it disappeared between 2200 and 1800 bc. The forces that propelled its expansion are a matter of long-standing debate, and there is support for both cultural diffusion and migration having a role in this process. Here we present genome-wide data from 400 Neolithic, Copper Age and Bronze Age Europeans, including 226 individuals associated with Beaker-complex artefacts. We detected limited ...
107 CitationsSource
#1Iain Mathieson (UPenn: University of Pennsylvania)H-Index: 21
#2Songül Alpaslan-Roodenberg (Harvard University)H-Index: 4
Last. David Reich (Broad Institute)H-Index: 109
view all 117 authors...
Genome-wide ancient DNA data from 225 individuals who lived in southeastern Europe between 12000 and 500 bc reveals that the region acted as a genetic crossroads before and after the arrival of farming.
97 CitationsSource
#1Magdalena Fraser (Uppsala University)H-Index: 4
#2Federico Sánchez-Quinto (Uppsala University)H-Index: 10
Last. Mattias Jakobsson (Uppsala University)H-Index: 41
view all 8 authors...
In recent years it has been shown that the Neolithization of Europe was partly driven by migration of farming groups admixing with local hunter-gatherer groups as they dispersed across the continen ...
7 CitationsSource
#1Torsten Günther (Uppsala University)H-Index: 17
#2Helena Malmström (Uppsala University)H-Index: 17
Last. Mattias Jakobsson (Uppsala University)H-Index: 41
view all 27 authors...
Scandinavia was one of the last geographic areas in Europe to become habitable for humans after the Last Glacial Maximum (LGM). However, the routes and genetic composition of these postglacial migrants remain unclear. We sequenced the genomes, up to 57× coverage, of seven hunter-gatherers excavated across Scandinavia and dated from 9,500–6,000 years before present (BP). Surprisingly, among the Scandinavian Mesolithic individuals, the genetic data display an east–west genetic gradient that oppose...
35 CitationsSource
#1Mark LipsonH-Index: 13
Last. David ReichH-Index: 109
view all 57 authors...
In European Neolithic populations, the arrival of farmers prompted admixture with local hunter-gatherers over many centuries, resulting in distinct signatures in each region due to a complex series of interactions.
67 CitationsSource
#1Torsten Günther (Uppsala University)H-Index: 17
#2Helena Malmström (Uppsala University)H-Index: 17
Last. Mattias Jakobsson (Uppsala University)H-Index: 41
view all 27 authors...
Scandinavia was one of the last geographic areas in Europe to become habitable for humans after the last glaciation. However, the origin(s) of the first colonizers and their migration routes remain unclear. We sequenced the genomes, up to 57x coverage, of seven hunter-gatherers excavated across Scandinavia and dated to 9,500-6,000 years before present. Surprisingly, among the Scandinavian Mesolithic individuals, the genetic data display an east-west genetic gradient that opposes the pattern seen...
3 CitationsSource
#1Gloria Gonzalez-Fortes (University of Potsdam)H-Index: 6
#2Eppie R. Jones (University of Cambridge)H-Index: 11
Last. Michael Hofreiter (University of Potsdam)H-Index: 65
view all 17 authors...
This research was supported by a European Research Council (ERC) Starting Grant (ERC-2010-StG 263441) to R.P. G.G.-F. was also supported by MSC Individual Fellowship (NeoGenHeritage, grant no. 655478). E.R.J. was supported by a Herchel Smith Research Fellowship. M.H. and A.M. were supported by ERC consolidator grants 310763 GeneFlow and 647797 LocalAdaptation, respectively. V.S. was supported by the Gates Cambridge Trust. The work of C.L. was undertaken through the Partnerships in Priority Areas...
27 CitationsSource
Cited By7
Newest
#1Jasmin S. Rees (UCL: University College London)
#2Sergi Castellano (UCL: University College London)H-Index: 17
Last. Aida M. Andrés (UCL: University College London)H-Index: 24
view all 3 authors...
Modern humans inhabit a variety of environments and are exposed to a plethora of selective pressures, leading to multiple genetic adaptations to local environmental conditions. These include adaptations to climate, UV exposure, disease, diet, altitude, or cultural practice and have generated important genetic and phenotypic differences amongst populations. In recent years, new methods to identify the genomic signatures of natural selection underlying these adaptations, combined with novel types ...
Source
#1Dan Ju (UPenn: University of Pennsylvania)
#2Iain Mathieson (UPenn: University of Pennsylvania)H-Index: 21
Skin pigmentation is a classic example of a polygenic trait that has experienced directional selection in humans. Genome-wide association studies have identified well over a hundred pigmentation-associated loci, and genomic scans in present-day and ancient populations have identified selective sweeps for a small number of light pigmentation-associated alleles in Europeans. It is unclear whether selection has operated on all the genetic variation associated with skin pigmentation as opposed to ju...
Source
#1Samantha NeilH-Index: 3
#2Jane EvansH-Index: 38
Last. Chris ScarreH-Index: 13
view all 4 authors...
Source
#1Miriam Cubas (Ebor: University of York)H-Index: 7
#2Alexandre Lucquin (Ebor: University of York)H-Index: 13
Last. Ricardo A. Fernandes (Masaryk University)H-Index: 13
view all 23 authors...
The introduction of farming had far-reaching impacts on health, social structure and demography. Although the spread of domesticated plants and animals has been extensively tracked, it is unclear how these nascent economies developed within different environmental and cultural settings. Using molecular and isotopic analysis of lipids from pottery, here we investigate the foods prepared by the earliest farming communities of the European Atlantic seaboard. Surprisingly, we find an absence of aqua...
Source
In this paper we explore ancient DNA as a powerful new technique for archaeologists. We argue that for aDNA to reach its full potential we need to carefully consider its theoretical underpinnings. We suggest that at present much aDNA research rests upon two problematic theoretical assumptions: first, that nature and culture exist in binary opposition and that DNA is a part of nature; secondly, that cultures form distinct and bounded identities. The nature-culture binary, which underpins much aDN...
Source
#1Andrea Hanel (University of Eastern Finland)H-Index: 1
#2Carsten Carlberg (University of Eastern Finland)H-Index: 59
Abstract Vitamin D3 is produced non-enzymatically when the cholesterol precursor 7-dehydrocholesterol is exposed to UV-B, i.e., evolutionary the first function of the molecule was that of an UV-B radiation scavenging end product. Vitamin D endocrinology started when some 550 million years ago first species developed a vitamin D receptor (VDR) that binds with high affinity the vitamin D metabolite 1α,25-dihydroxyvitamin D3. VDR evolved from a subfamily of nuclear receptors sensing the levels of c...
2 CitationsSource
#1Kevan EdinboroughH-Index: 17
#2Stephen ShennanH-Index: 39
Last. Peter SchauerH-Index: 1
view all 11 authors...
1 CitationsSource
Skin pigmentation is a complex, conspicuous, highly variable human trait that exhibits a remarkable correlation with latitude. The evolutionary history and genetic basis of skin color variation has been the subject of intense research in the last years. This article reviews the major hypotheses explaining skin color diversity and explores the implications of recent findings about the genes associated with skin pigmentation for understanding the evolutionary forces that have shaped the current pa...
1 CitationsSource
#1Edward R. TreasureH-Index: 2
#2Darren R. GröckeH-Index: 35
Last. Mike J. ChurchH-Index: 22
view all 4 authors...
The introduction of agriculture is a key defining element of the Neolithic, yet considerable debate persists concerning the nature and significance of early farming practices in north-west Europe. This paper reviews archaeobotanical evidence from 95 Neolithic sites (c. 4000–2200 cal bc) in Wales, focusing on wild plant exploitation, the range of crops present, and the significance of cereals in subsistence practices. Cereal cultivation practices in Early Neolithic Wales are also examined using c...
Source
#1T. Z. T. Jensen (Ebor: University of York)
#2Jonas Niemann (Ebor: University of York)H-Index: 1
Last. Hannes Schroeder (UCPH: University of Copenhagen)H-Index: 17
view all 22 authors...
The rise of ancient genomics has revolutionised our understanding of human prehistory but this work depends on the availability of suitable samples. Here we present a complete ancient human genome and oral microbiome sequenced from a 5700 year-old piece of chewed birch pitch from Denmark. We sequence the human genome to an average depth of 2.3× and find that the individual who chewed the pitch was female and that she was genetically more closely related to western hunter-gatherers from mainland ...
1 CitationsSource