Repeated non‐invasive limb ischemic preconditioning attenuates myocardial ischemia‐reperfusion injury in diabetic rats by up‐regulating hexokinase II

Background Ischemic heart disease is the leading cause of mortality in patients with diabetes mellitus. Although remote ischemic preconditioning achieved by non‐invasively occluding the brachial artery (non‐invasive limb ischemic preconditioning, NLIP) lost its cardioprotection in diabetes, our recent study demonstrated that repeated NLIP (rNLIP, applying 3 cycles of 5 minutes occlusion/5 minutes reperfusion in a unilateral hindlimb daily for 3...