Zhengyuan Xia
University of Hong Kong
Publications 214
Published on Sep 5, 2019in Oxidative Medicine and Cellular Longevity4.87
Shaoqing Lei16
Estimated H-index: 16
(WHU: Wuhan University),
Wating Su6
Estimated H-index: 6
(WHU: Wuhan University)
+ 6 AuthorsMichaelGIRWIN34
Estimated H-index: 34
(HKU: University of Hong Kong)
Diabetic hearts are more vulnerable to ischemia/reperfusion (I/R) injury and less responsive to remifentanil preconditioning (RPC), but the underlying mechanisms are incompletely understood. Caveolin-3 (Cav-3), the dominant isoform of cardiomyocyte caveolae, is reduced in diabetic hearts in which oxidative stress is increased. This study determined whether the compromised RPC in diabetes was an independent manifestation of hyperglycemia-induced oxidative stress or linked to impaired Cav-3 expres...
Published on Aug 1, 2019in Cell Death and Disease5.96
Lingbin Sun (JNU: Jinan University), Wei Ma (JNU: Jinan University)+ 5 AuthorsZhongliang Dai (JNU: Jinan University)
Propofol infusion syndrome (PRIS) is an uncommon life-threatening complication observed most often in patients receiving high-dose propofol. High-dose propofol treatment with a prolonged duration can damage the immune system. However, the associated molecular mechanisms remain unclear. An increasing number of clinical and experimental observations have demonstrated that tissue-resident macrophages play a critical role in immune regulation during anaesthesia and procedural sedation. Since the inf...
Published on Jan 1, 2019in International Heart Journal2.23
Zhi-Dong Ge22
Estimated H-index: 22
(WMU: Wenzhou Medical College),
Qingquan Lian17
Estimated H-index: 17
(WMU: Wenzhou Medical College)
+ 1 AuthorsZhengyuan Xia32
Estimated H-index: 32
(WMU: Wenzhou Medical College)
Published on Apr 17, 2019in Oxidative Medicine and Cellular Longevity4.87
Liang Ge3
Estimated H-index: 3
(JLU: Jilin University),
Yin Cai7
Estimated H-index: 7
(HKU: University of Hong Kong)
+ 8 AuthorsAimin Xu68
Estimated H-index: 68
(HKU: University of Hong Kong)
Background. Activation of cell apoptosis is a major form of cell death during myocardial ischemia/reperfusion injury (I/RI). Therefore, examining ways to control cell apoptosis has important clinical significance for improving postischemic recovery. Clinical evidence demonstrated that miR-181c-5p was significantly upregulated in the early phase of myocardial infarction. However, whether or not miR-181c-5p mediates cardiac I/RI through cell apoptosis pathway is unknown. Thus, the present study is...
Published on Apr 1, 2019in The FASEB Journal5.39
Dengwen Zhang , Sheng Wang3
Estimated H-index: 3
+ 3 AuthorsZhengyuan Xia32
Estimated H-index: 32
Background Ischemic heart disease is the leading cause of mortality in patients with diabetes mellitus. Although remote ischemic preconditioning achieved by non-invasively occluding the brachial artery (non-invasive limb ischemic preconditioning, NLIP) lost its cardioprotection in diabetes, our recent study demonstrated that repeated NLIP (rNLIP, applying 3 cycles of 5 minutes occlusion/5 minutes reperfusion in a unilateral hindlimb daily for 3 days) reduced myocardial infarction, but the mechan...
Published on Apr 1, 2019in Journal of Molecular and Cellular Cardiology5.05
Tian-Tian Wang3
Estimated H-index: 3
(SYSU: Sun Yat-sen University),
Mao-Mao Shi2
Estimated H-index: 2
(SYSU: Sun Yat-sen University)
+ 15 AuthorsYue-Ming Peng (SYSU: Sun Yat-sen University)
Abstract Ischemia postconditioning (PTC) can reduce myocardial ischemia/reperfusion injury. However, the effectiveness of PTC cardioprotection is reduced or lost in diabetes and the mechanisms are largely unclear. Hyperglycemia can induce overexpression of inducible nitric oxide synthesis (iNOS) in the myocardium of diabetic subjects. However, it is unknown whether or not iNOS especially its overexpression plays an important role in the loss of cardioprotection of PTC in diabetes. C57BL6 and iNO...
Published on Mar 14, 2019in Mediators of Inflammation3.54
Dan Zhu (Southwest General Health Center), Tingting Fan (HKU: University of Hong Kong)+ 3 AuthorsZhengyuan Xia32
Estimated H-index: 32
(HKU: University of Hong Kong)
Diabetic neuropathic pain (DNP) is a common and serious complication of diabetic patients. The pathogenesis of DNP is largely unclear. The proinflammation proteins, CXCR4, and TNF-α play critical roles in the development of pain, while their relative roles in the development of DNP and especially its progression is unknown. We proposed that establishment of diabetic pain models in rodents and evaluating the stability of behavioral tests are necessary approaches to better understand the mechanism...
Published on Mar 1, 2019in BJA: British Journal of Anaesthesia6.20
Chen-yi Yang1
Estimated H-index: 1
(Tianjin Medical University),
Huo Wang1
Estimated H-index: 1
(Tianjin Medical University)
+ 9 AuthorsX.Y. Wang (Tianjin Medical University)
Published on Jan 1, 2019in Cardiovascular Research7.01
Yanan Liu13
Estimated H-index: 13
(Columbia University),
Mark Paterson4
Estimated H-index: 4
(MCW: Medical College of Wisconsin)
+ 4 AuthorsZhi-Dong Ge22
Estimated H-index: 22
(Stanford University)
Published on Sep 1, 2018in Biochimica et Biophysica Acta3.79
Fan Ying2
Estimated H-index: 2
(Li Ka Shing Faculty of Medicine, University of Hong Kong),
Yin Cai7
Estimated H-index: 7
(Li Ka Shing Faculty of Medicine, University of Hong Kong)
+ 6 AuthorsEva Hoi Ching Tang4
Estimated H-index: 4
(Li Ka Shing Faculty of Medicine, University of Hong Kong)
Abstract Prostaglandin E receptor subtype 4 (EP4) knockout mice develops spontaneous hypercholesterolemia but the detailed mechanisms by which EP4 affects cholesterol homeostasis remains unexplored. We sought to determine the cause of hypercholesterolemia in EP4 knockout mice, focusing on the role of EP4 in regulating the synthesis and elimination of cholesterol. Deficiency of EP4 significantly decreased total bile acid levels in the liver by 26.2% and the fecal bile acid content by 27.6% as com...