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Zhengyuan Xia
University of Hong Kong
EndocrinologyAnesthesiaIschemiaDiabetes mellitusMedicine
214Publications
32H-index
3,184Citations
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Publications 271
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#1Zhengyuan Xia (Li Ka Shing Faculty of Medicine, University of Hong Kong)H-Index: 32
1 CitationsSource
#1Lie-Hua DengH-Index: 1
#2Shaoqing Lei (WHU: Wuhan University)H-Index: 17
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Coronavirus disease-2019 (COVID-19) has rapidly spread worldwide. High-flow nasal cannula therapy (HFNC) is a major oxygen supporting therapy for severely ill patients, but information regarding the timing of HFNC application is scarce, especially in elderly patients. We retrospectively analyzed the clinical data of 110 elderly patients (≥65 years) who received HFNC from Renmin Hospital of Wuhan University, People9s Hospital of Xiantao City and Chinese Medicine Hospital of Shishou City in Hubei ...
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#1Dan Yan (SZU: Shenzhen University)H-Index: 4
#2Yin Cai (HKU: University of Hong Kong)H-Index: 7
Last. Zhengyuan Xia (HKU: University of Hong Kong)H-Index: 32
view all 10 authors...
Forkhead box protein O1 (FOXO1), a nuclear transcription factor, is preferably activated in the myocardium of diabetic mice. However, its role and mechanism in the development of diabetic cardiomyopathy in non-obese insulin-deficient diabetes are unclear. We hypothesized that cardiac FOXO1 over-activation was attributable to the imbalanced myocardial oxidative metabolism and mitochondrial and cardiac dysfunction in type 1 diabetes. FOXO1-selective inhibitor AS1842856 was administered to streptoz...
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#1Chunyan Wang (JNU: Jinan University)H-Index: 3
#2Wenlin Yuan (JNU: Jinan University)H-Index: 1
Last. Zhongjun Zhang (JNU: Jinan University)H-Index: 4
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Cardiac dysfunction resulting from sepsis may cause significant morbidity and mortality, and ferroptosis plays a role in this pathology. Dexmedetomidine (Dex), a alpha2adrenergic receptor (alpha2AR) agonist exerts cardioprotective effects against septic heart dysfunction, but the exact mechanism is unknown. In the present study, sepsis was induced by cecal ligation and puncture (CLP) in male C57BL/6 mice. Dex and yohimbine hydrochloride (YOH), an alpha2AR inhibitor, were administered before indu...
4 CitationsSource
#1Shaoqing Lei (WHU: Wuhan University)H-Index: 17
#2Fang Jiang (HKU: University of Hong Kong)H-Index: 2
Last. Zhengyuan Xia (HKU: University of Hong Kong)H-Index: 32
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1 CitationsSource
#1Chunyan Wang (JNU: Jinan University)H-Index: 3
#2Lijie Zhu (JNU: Jinan University)
Last. Weifeng Yao (SYSU: Sun Yat-sen University)H-Index: 13
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Cardiovascular diseases such as myocardial ischaemia have a high fatality rate in patients with diabetes. This study was designed to expose the crosstalk between oxidative stress and AMPK, a vital molecule that controls biological energy metabolism, in myocardial ischaemia reperfusion injury (I/RI) in diabetic rats. Diabetes was stimulated in rats using streptozotocin injection. Rats were separated on random into control, control + I/R, Diabetes, Diabetes + I/R, Diabetes + I/R + N-acetylcysteine...
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#1Binbin Wu (CAS: Chinese Academy of Sciences)H-Index: 2
#2Huachang Hong (ZJNU: Zhejiang Normal University)H-Index: 22
Last. Yan Liang (CAS: Chinese Academy of Sciences)H-Index: 25
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Abstract Disinfection by-products (DBPs) are generated during chlorination of drinking water. Previous studies demonstrate that DBPs are cytotoxic, genotoxic and associated with an increased risk of human cancer. However, the molecular basis of DBPs-induced toxic effects remains unclear. Here, we chlorinated samples of algal-derived organic matter (AOM) and sediment organic matter (SOM) from a local drinking water reservoir. Chemical properties, toxicities and transcriptomic profiles of human Ca...
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#1Yafeng Wang (WHU: Wuhan University)H-Index: 1
#2Lu Zhou (WHU: Wuhan University)H-Index: 1
Last. Shaoqing Lei (WHU: Wuhan University)H-Index: 17
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Diabetic hearts are more susceptible to myocardial ischemia/reperfusion (I/R) injury and less sensitive to ischemic postconditioning (IPostC), but the underlying mechanisms remain unclear. PKCbeta2 is preferentially overactivated in diabetic myocardium, in which autophagy status is abnormal. This study determined whether hyperglycemia-induced PKCbeta2 activation resulted in autophagy abnormality and compromised IPostC cardioprotection in diabetes. We found that diabetic rats showed higher cardia...
2 CitationsSource
#2Hong Han (Guangzhou Medical University)
Last. Zhengyuan Xia (HKU: University of Hong Kong)H-Index: 32
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#1Xiaodong Ye (HKU: University of Hong Kong)
#2Yin Cai (HKU: University of Hong Kong)H-Index: 7
Last. Zhengyuan Xia (HKU: University of Hong Kong)H-Index: 32
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