Assessing the Role of 98 Established Loci for BMI in American Indians

Objective Meta‐analyses of genome‐wide association studies in Europeans have identified > 98 loci for BMI. Transferability of these established associations in Pima Indians was analyzed. Methods Among 98 lead single nucleotide polymorphisms (SNPs), 82 had minor allele frequency ≥ 0.01 in Pima Indians and were analyzed for association with the maximum BMI in adulthood ( n = 3,491) and BMI z score in childhood ( n = 1,958). Common tag SNPs...