RARE AND DE NOVO VARIANTS IN OBSESSIVE COMPULSIVE DISORDER

Obsessive Compulsive Disorder (OCD) is a complex neuropsychiatric disorder that affects approximately 1% of the population. It is likely that the genetic architecture underlying the disorder is complex, and that furthermore some subset of it involves rare and de novo variants of relatively large effect size. We have generated what to our knowledge is the largest high throughput sequencing dataset for this disorder presently in existence. The...