The Activated Protein C (APC) Response to In vivo Thrombin Formation Correlates with the Thrombotic Risk in Factor V Leiden but not in Prothrombin G20210A Carriers
Abstract
Objectives: Factor V Leiden (FVL) and prothrombin G20210A (PRO) are the most frequent genetic risk factors for venous thromboembolism (VTE). Recently, we have shown increased generation of activated protein C (APC) in asymptomatic FVL carriers (VTE-) in response to thrombin formation, induced by recombinant activated factor VII (rFVIIa) in vivo (Rühl et al. Blood 2018;131:1489–1492). Aim of the present study was to extend this approach to...
Paper Details
Title
The Activated Protein C (APC) Response to In vivo Thrombin Formation Correlates with the Thrombotic Risk in Factor V Leiden but not in Prothrombin G20210A Carriers
Published Date
Feb 1, 2019
Journal
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