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Bernd Pötzsch
University Hospital Bonn
116Publications
25H-index
3,147Citations
Publications 116
Newest
Published on Jun 16, 2019in Thrombosis and Haemostasis4.73
Jens Müller22
Estimated H-index: 22
(University of Bonn),
Isabell Pekrul1
Estimated H-index: 1
(LMU: Ludwig Maximilian University of Munich)
+ 3 AuthorsMichael Spannagl40
Estimated H-index: 40
(LMU: Ludwig Maximilian University of Munich)
Hemophilia A (HA) is an X-linked hereditary bleeding disorder caused by deficiency of coagulation factor (F) VIII activity. One of the greatest complications in the treatment of HA is the development of neutralizing alloantibodies, known as FVIII inhibitors. HA patients who develop FVIII inhibitors have limited treatment options available to them and experience greater disease- and treatment-related burdens than HA patients without FVIII inhibitors. Emicizumab, a recently approved bispecific mon...
Published on Jul 17, 2019in Circulation Research15.86
Heiko Rühl6
Estimated H-index: 6
(University Hospital Bonn),
Christina Berens2
Estimated H-index: 2
(University Hospital Bonn)
+ 4 AuthorsBernd Pötzsch25
Estimated H-index: 25
(University Hospital Bonn)
Rationale: Carriers of the most common prothrombotic mutations factor V Leiden (FVL) and prothrombin (FII) 20210G>A show a highly variable clinical phenotype. Using standardized in vivo coagulation...
Published on Apr 11, 2019in Journal of Medicinal Chemistry1.51
Charlotte A. Bäuml2
Estimated H-index: 2
(University of Bonn),
Thomas Schmitz3
Estimated H-index: 3
(University of Bonn)
+ 9 AuthorsJ. Oldenburg59
Estimated H-index: 59
(University Hospital Bonn)
Tridegin is a potent and specific 66mer peptide inhibitor of coagulation factor XIIIa with six cysteines involved in three disulfide bonds. Three of the 15 possible 3-disulfide-bonded isomers have been identified, which share a bridge between cysteines 19 and 25. We synthesized the three possible 2-disulfide-bonded analogues using a targeted protecting group strategy to investigate the impact of the C19–C25 bond on tridegin’s folding, stability, and function. The FXIIIa inhibitory activity of th...
Published on Feb 1, 2019
Heiko Rühl6
Estimated H-index: 6
(University Hospital Bonn),
S. Reda (University Hospital Bonn)+ 4 AuthorsBernd Pötzsch25
Estimated H-index: 25
(University Hospital Bonn)
Published on Feb 1, 2019
S. Reda (University Hospital Bonn), Heiko Rühl6
Estimated H-index: 6
(University Hospital Bonn)
+ 3 AuthorsBernd Pötzsch25
Estimated H-index: 25
(University Hospital Bonn)
Published on Feb 1, 2019
V. Ivaškevičius (University Hospital Bonn), Arijit Biswas1
Estimated H-index: 1
(University Hospital Bonn)
+ 3 AuthorsJ. Oldenburg59
Estimated H-index: 59
(University Hospital Bonn)
Published on Feb 1, 2019
Jens Müller22
Estimated H-index: 22
(University Hospital Bonn),
S. Gasper (University Hospital Bonn)+ 3 AuthorsBernd Pötzsch25
Estimated H-index: 25
(University Hospital Bonn)
Published on Feb 1, 2019
Christina Berens2
Estimated H-index: 2
(University Hospital Bonn),
Heiko Rühl6
Estimated H-index: 6
(University Hospital Bonn)
+ 2 AuthorsBernd Pötzsch25
Estimated H-index: 25
(University Hospital Bonn)
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