KLOTHO heterozygosity attenuates APOE4-related amyloid burden in preclinical AD
Abstract
To examine whether the KLOTHO gene variant KL-VS attenuates APOE4-associated β-amyloid (Aβ) accumulation in a late-middle-aged cohort enriched with Alzheimer disease (AD) risk factors.Three hundred nine late-middle-aged adults from the Wisconsin Registry for Alzheimer's Prevention and the Wisconsin Alzheimer's Disease Research Center were genotyped to determine KL-VS and APOE4 status and underwent CSF sampling (n = 238) and/or 11C-Pittsburgh...
Paper Details
Title
KLOTHO heterozygosity attenuates APOE4-related amyloid burden in preclinical AD
Published Date
Apr 16, 2019
Journal
Volume
92
Issue
16
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