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#2Francesca BeccariaH-Index: 23
Last. Giuseppe CapovillaH-Index: 37
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Hypocalcemia is a condition in which total serum calcium concentration is <8.5 mg/dL or ionized calcium concentration is <4 mg/dL. Severe vitamin D deficiency, disorders of parathyroid hormone (PTH), and drug intake are the most common causes of hypocalcemia.1
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#1Sanskriti Sasikumar (U of T: University of Toronto)
#2Jose Danilo B. Diestro (St. Michael's Hospital)H-Index: 1
The educational experience of a neurology trainee can have profound regional variations. We recount the management of a code stroke in Toronto, Canada and Manila, Philippines as a means to highlight the need for collaborative learning, both in terms of practicing evidence-based medicine and managing neurological conditions in resource-limited settings. Concerted peer-led initiatives such as videoconference rounds are an easy and cost-effective means of unifying this experience.
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#1Kelly L. Sloane (Harvard University)H-Index: 4
For there is nothing heavier than compassion. Not even one's own pain weighs so heavy as the pain one feels with someone, for someone, a pain intensified by the imagination and prolonged by a hundred echoes.— Milan Kundera, The Unbearable Lightness of Being1
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#### Notable in Neurology this week This issue features an article that investigates the genotype-phenotype correlation between neurofibromatosis 1 germline mutations and imaging features of neurofibromas on whole-body MRI; another suggests that identifying the index vein on susceptibility-weighted MRI during a migraine attack can point to the cortical area responsible for the aura symptoms. A featured Views & Reviews explores a sign-based approach …
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#1Pavel AtanasovH-Index: 9
Last. Jonathan KimmelmanH-Index: 26
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OBJECTIVE To explore the accuracy of combined neurology expert forecasts in predicting primary endpoints for trials. METHODS We identified one major randomized trial each in stroke, multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS) that was closing within 6 months. After recruiting a sample of neurology experts for each disease, we elicited forecasts for the primary endpoint outcomes in the trial placebo and treatment arms. Our main outcome was the accuracy of averaged predictions...
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X-linked adrenoleukodystrophy (ALD) is the most common inherited leukodystrophy (1:15,000 birth incidence) and is caused by mutations in the ABCD1 gene leading to accumulation of very long chain fatty acids.1,2 The ALD genotype confers several independent but overlapping phenotypes: adrenal insufficiency, adrenomyeloneuropathy (an adult-onset spastic paraplegia and neuropathy syndrome), and cerebral ALD (cALD). The dreaded cALD phenotype is characterized by the appearance of inflammatory demyeli...
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I read with interest the article by Nitta et al.1 A validated biofluid (blood or CSF) or imaging biomarker for sports-related concussion (SRC) remains elusive, but the search continues. Different grades of SRC are encountered, ranging from a football player getting his bell rung, but with no accompanying loss of consciousness, to an athlete getting knocked out in the field with accompanying loss of consciousness and posttraumatic amnesia of varying duration. Did the levels of the serum inflammat...
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#1Eric J. MallackH-Index: 1
Last. Florian EichlerH-Index: 27
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Objective To gain insight into the natural history of arrested cerebral adrenoleukodystrophy (CALD) by quantifying the change in Neurologic Function Score (NFS) and Loes Score (LS) over time in patients whose cerebral lesions spontaneously stopped progressing. Methods We retrospectively reviewed a series of 22 patients with arrested CALD followed longitudinally over a median time of 2.4 years (0.7–17.0 years). Primary outcomes were change in radiographic disease burden (measured by LS) and clini...
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#1Elie NaddafH-Index: 5
#2Margherita MiloneH-Index: 34
Last. Taxiarchis V. KourelisH-Index: 1
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We thank Drs. Chahin and Karam for their constructive comments on our article.1 There was no difference in the Neuropathy Impairment Score-Weakness2 at presentation between patients treated with intravenous immunoglobulin (IVIG) and autologous stem cell transplant (ASCT) (median: 27.5 vs 26.25, respectively).
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In the article “Acute elevation of serum inflammatory markers predicts symptom recovery after concussion,” Drs. Nitta et al. studied serum inflammatory markers in 41 high school and collegiate football players with sports-related concussion (SRC) and 43 matched control athletes, and they collected symptom severity scores at a preinjury baseline and at several time points up to 45 days postconcussion. They found that interleukin-6 (IL-6) and IL-1RA were significantly elevated in SRC at 6 hours vs...
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