The Other Glucose Transporter, SGLT1 – Also a Potential Trouble Maker in Diabetes?

Diabetes mellitus, characterized by abnormal insulin secretion or resistance accompanied by hyperglycemia is an increasing problem worldwide, which results in various vascular pathologies, including diabetic nephropathies, and increased risk of developing CKD and ESRD.1 Hyperglycemia-induced glomerular hyperfiltration, which has been hypothesized to predispose to irreversible nephron damages, is observed early in the history of as many as 70% of...