Longitudinal proton spectroscopy study of the prefrontal cortex in youth at risk for bipolar disorder before and after their first mood episode

Objectives To investigate neurochemical abnormalities in the left and right ventrolateral prefrontal cortex (VLPFC) and anterior cingulate cortex (ACC) of youth at risk for bipolar disorder using proton magnetic resonance spectroscopy before and after their first mood episode. Methods Children and adolescents offspring of parents with bipolar I disorder (at‐risk group, n = 117) and matched healthy controls (HC group, n = 61) were recruited at...