Evaluating and Enhancing Target Specificity of Gene-Editing Nucleases and Deaminases
Abstract
Programmable nucleases and deaminases, which include zinc-finger nucleases, transcription activator-like effector nucleases, CRISPR RNA-guided nucleases, and RNA-guided base editors, are now widely employed for the targeted modification of genomes in cells and organisms. These gene-editing tools hold tremendous promise for therapeutic applications. Importantly, these nucleases and deaminases may display off-target activity through the...
Paper Details
Title
Evaluating and Enhancing Target Specificity of Gene-Editing Nucleases and Deaminases
Published Date
Jun 20, 2019
Volume
88
Issue
1
Pages
191 - 220
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