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Parental depression moderates the relationships of cortisol and testosterone with children's symptoms

Published on May 1, 2019in Journal of Affective Disorders 4.08
· DOI :10.1016/j.jad.2019.01.047
Sarah R. Black (UNO: University of New Orleans), Brandon L. Goldstein5
Estimated H-index: 5
(SBU: Stony Brook University),
Daniel N. Klein72
Estimated H-index: 72
(SBU: Stony Brook University)
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Abstract
Abstract Background Previous research on the hormone-symptom relationship in children suggests that certain hormone patterns may be associated with symptoms, but only under certain circumstances. Having a parent with a history of depression may be one circumstance under which dysregulated hormone patterns are especially associated with emotional and behavioral symptoms in children. The current study sought to explore these relationships in a community sample of 389 9-year-old children. Methods Children's salivary cortisol and testosterone levels were collected at home over three consecutive days; parental psychiatric histories were assessed using semi-structured diagnostic interviews; and children's internalizing and externalizing symptoms were rated by the child's mother. Results Having two parents with a history of depression moderated the associations of reduced total daily cortisol output with higher externalizing scores, as well as the association of reduced testosterone with higher internalizing scores. A maternal history of depression, on the other hand, moderated the relationship between higher cortisol awakening response and higher internalizing scores. Furthermore, lower daily cortisol output was associated with higher internalizing scores among girls, but not boys, with two parents with a history depression. Limitations Limitations include the cross-sectional nature of the current analyses, as well as the limited racial, ethnic, and geographical diversity of the sample. Conclusions Taken together, the current results suggest that the relationship between hormones and internalizing and externalizing symptoms in children may vary as a function of parental depression and child sex, knowledge that may inform intervention efforts aimed at preventing psychopathology in children whose parents have a history of depression.
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Published on Apr 1, 2018in Journal of Child Psychology and Psychiatry 6.13
Kalsea J. Koss11
Estimated H-index: 11
(Office of Population Research),
Megan R. Gunnar80
Estimated H-index: 80
(UMN: University of Minnesota)
Background Research on early adversity, stress biology, and child development has grown exponentially in recent years. Findings We review the current evidence for the hypothalamic–pituitary–adrenocortical (HPA) axis as a stress-mediating mechanism between various forms of childhood adversity and psychopathology. We begin with a review of the neurobiology of the axis and evidence for relations between early adversity–HPA axis activity and HPA axis activity–psychopathology, as well as discuss the ...
24 Citations Source Cite
Published on Dec 1, 2017in Child Development Perspectives 4.43
Daniel N. Klein72
Estimated H-index: 72
(SBU: Stony Brook University),
Megan Finsaas4
Estimated H-index: 4
(SBU: Stony Brook University)
In this article, we summarize findings from the Stony Brook Temperament Study, which seeks to elucidate the early antecedents and pathways to later depressive and anxiety disorders. The study focuses on parents’ internalizing disorders and children's early temperament as distal risk factors that operate, in part, through biobehavioral reward and threat systems. We summarize findings linking parents’ emotional disorders and observations of children's early temperament to subsequent neural measure...
3 Citations Source Cite
Published on Dec 1, 2017in Journal of Adolescent Health 3.96
Keke L. Schuler2
Estimated H-index: 2
(UNT: University of North Texas),
Camilo J. Ruggero18
Estimated H-index: 18
(UNT: University of North Texas)
+ 3 AuthorsRoman Kotov36
Estimated H-index: 36
(SBU: Stony Brook University)
Abstract Purpose The aim of present study was to test the diathesis-stress model of depression using baseline cortisol, prospective assessment of depression symptoms, and stressful life events. Methods The sample consisted of 527 adolescent girls aged 13.5–15.5 years without major depressive disorder. At baseline, saliva samples were collected at waking, 30 minutes after waking, and 8 p.m. on 3 consecutive days. Diurnal cortisol was indexed by cortisol awakening response (CAR) and area under the...
7 Citations Source Cite
Published on Jun 1, 2016in Journal of Social and Personal Relationships 1.68
Liesel L. Sharabi4
Estimated H-index: 4
(UIUC: University of Illinois at Urbana–Champaign),
Amy L. Delaney4
Estimated H-index: 4
(UIUC: University of Illinois at Urbana–Champaign),
Leanne K. Knobloch27
Estimated H-index: 27
(UIUC: University of Illinois at Urbana–Champaign)
This study adopts an inductive and dyadic approach to illuminate how depression affects romantic relationships in people’s own words. Depressed couples (N = 135) responded to an open-ended item about ways that depression influences their romantic relationship. Content analytic results indicated eight categories of negative effects (emotional toll, romance and sexual intimacy, communication, isolation, lack of energy/motivation, dependence on the relationship, lack of understanding, and uncertain...
9 Citations Source Cite
Published on Feb 1, 2016in Psychoneuroendocrinology 4.01
Cynthia R. Murray1
Estimated H-index: 1
(NeuRA: Neuroscience Research Australia),
Julian G. Simmons24
Estimated H-index: 24
(University of Melbourne)
+ 6 AuthorsSarah Whittle31
Estimated H-index: 31
(University of Melbourne)
Early timing of adrenarche, associated with relatively high levels of dehydroepiandrosterone (DHEA) and its sulphate (DHEA-S) in children, has been linked with mental health problems, particularly anxiety. However, little is known about possible neurobiological mechanisms underlying this association. The pituitary gland is a key component of the hypothalamic–pituitary–adrenal (HPA) axis, the activation of which triggers the onset of adrenarche. The purpose of this study was to examine the extent...
7 Citations Source Cite
Published on Jan 1, 2016in Nursing Research 2.02
Licia M. Clowtis1
Estimated H-index: 1
(University of Texas at Austin),
Duck Hee Kang3
Estimated H-index: 3
+ 2 AuthorsMichelle S. Barratt11
Estimated H-index: 11
Background: Exposure to high levels of maternal stress and ineffective maternal–child engagement (MC-E) may adversely affect child health-related outcomes. Objective: The aim of this study was to examine the impact of maternal stress and MC-E on maternal and child biological responses (salivary cortisol and testosterone) and child health outcome in mother–child dyads of preschool children (3–5.9 years) in a low socioeconomic setting. Methods: Observational and biobehavioral data were collected f...
4 Citations Source Cite
Published on Dec 1, 2015in Journal of Adolescent Health 3.96
Lisa K. Mundy9
Estimated H-index: 9
(University of Melbourne),
Helena Romaniuk17
Estimated H-index: 17
+ 7 AuthorsGeorge C. Patton85
Estimated H-index: 85
(University of Melbourne)
Abstract Purpose Mental and behavioral disorders increase in prevalence with the passage through puberty. Yet the first symptoms for many children emerge between seven and 11 years, before the pubertal rise in gonadal hormones. A possibility that symptom onset may be linked to the adrenarchal rise in androgens has been little explored. Methods The Childhood to Adolescence Transition Study recruited a stratified random sample of 1,239 eight–nine year olds from primary schools in Melbourne, Austra...
11 Citations Source Cite
Published on Aug 1, 2015in Journal of Affective Disorders 4.08
Becky Mars13
Estimated H-index: 13
(UoB: University of Bristol),
Stephan Collishaw30
Estimated H-index: 30
(Cardiff University)
+ 10 AuthorsNicolas Craddock1
Estimated H-index: 1
(Cardiff University)
BACKGROUND: Major depressive disorder (MDD) is common and is associated with an increased risk of psychopathology in offspring. However, depression shows considerable heterogeneity in its course over time. The aim of this study is to examine the relationship between parent depression symptom trajectories and (i) quality of life and social impairment and (ii) psychiatric disorder and depression symptoms in their offspring. METHOD: Participants were from a longitudinal study of 337 parents with re...
13 Citations Source Cite
Published on Mar 1, 2015in Journal of Research on Adolescence 2.07
Ben T. Reeb6
Estimated H-index: 6
(UC Davis: University of California, Davis),
Ed Y. Wu3
Estimated H-index: 3
(UC Davis: University of California, Davis)
+ 3 AuthorsKatherine J. Conger20
Estimated H-index: 20
(UC Davis: University of California, Davis)
While an accumulating body of research has documented increased risk of psychopathology among children of depressed fathers, most studies have used cross-sectional design, and little is known about offspring outcomes beyond childhood. Using prospective data from a community sample (N = 395), we found that paternal depressive symptoms when children were in early adolescence (age 13) predicted offspring depressive and anxiety symptoms at age 21, controlling for baseline youth symptoms, maternal de...
15 Citations Source Cite