Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains
Abstract
The cytoplasmic accumulation of the nuclear TAR DNA-binding protein 43 (TDP-43) is a pathologic hallmark in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and other neurological disorders. However, most transgenic TDP-43 rodent models show predominant nuclear distribution of TDP-43 in the brain. By expressing mutant TDP-43 (M337V) in the brains of rhesus monkeys and mice, we verified that mutant TDP-43 is distributed in the...
Paper Details
Title
Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains
Published Date
Feb 27, 2019
Journal
Volume
137
Issue
6
Pages
919 - 937
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