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Prevalence of Fetal Alcohol Exposure by Analysis of Meconium Fatty Acid Ethyl Esters; A National Canadian Study

Published on Feb 19, 2019in Scientific Reports 4.01
· DOI :10.1038/s41598-019-38856-5
Kaitlyn Delano3
Estimated H-index: 3
(U of T: University of Toronto),
Gideon Koren83
Estimated H-index: 83
(TAU: Tel Aviv University)
+ 1 AuthorsBhushan Kapur21
Estimated H-index: 21
(U of T: University of Toronto)
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Abstract
Our study aimed to estimate the prevalence of heavy fetal alcohol exposure through the analysis of meconium FAEEs as an objective biomarker of fetal exposure. We conducted a study on meconium samples collected nationwide through the Maternal-Infant Research on Environmental Chemicals (MIREC) Study Group. FAEE in meconium was quantified by an established headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry (SPME GC-MS). Out of 1315 samples collected in 10 Canadian obstetric units coast to coast between 2008-2011, the estimated prevalence of positive meconium FAEE ranged between 1.16% and 2.40%, translating into at least 1800 new cases of FASD in Canada each year. Positive maternal self- reports of heavy alcohol use were tenfold lower (0.24%). Use of meconium FAEE revealed tenfold more cases of heavy exposure to maternal drinking than did maternal reports. The use of objective measures of maternal alcohol exposure is critical in accurately estimating risks and in monitoring effective prevention of FASD.
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References43
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Published on May 1, 2017in Alcoholism: Clinical and Experimental Research 3.23
Ludmila N. Bakhireva17
Estimated H-index: 17
(UNM: University of New Mexico),
Janet Sharkis1
Estimated H-index: 1
+ 3 AuthorsRajesh C. Miranda34
Estimated H-index: 34
(Texas A&M Health Science Center College of Medicine)
Background While 2 to 5% of school-aged children in the United States are estimated to be affected by fetal alcohol spectrum disorders (FASD), the prevalence of prenatal alcohol exposure (PAE) might be substantially underreported. Our objective was to systematically estimate the prevalence of PAE in Texas by measuring a direct ethanol metabolite, phosphatidylethanol (PEth), in 1,000 infant residual dried blood spots (irDBSs) in the Texas Newborn Screening Repository. Methods All public health re...
Published on Oct 1, 2015in Journal of Epidemiology and Community Health 3.87
Oriol Vall30
Estimated H-index: 30
,
Judith Salat-Batlle7
Estimated H-index: 7
,
Oscar Garcia-Algar28
Estimated H-index: 28
Lack of evidence is not the same as evidence of absence of risk and, in this case, no evidence of harm does not mean evidence of no harm; subsequently, no amount of alcohol during pregnancy can be considered safe based on research evidence. Newborns exposed to maternal alcohol during pregnancy can develop a spectrum of characteristic facial features, impaired neurodevelopment, cognitive and behavioural disabilities, and fetal growth restriction known as fetal alcohol spectrum disorder (FASD), wi...
Published on Mar 1, 2015in Clinical Chemistry 6.89
Sarah K. Himes7
Estimated H-index: 7
(NIDA: National Institute on Drug Abuse),
Kimberly Dukes12
Estimated H-index: 12
+ 9 AuthorsCaroline Signore19
Estimated H-index: 19
(NIH: National Institutes of Health)
Background: We investigated agreement between self-reported prenatal alcohol exposure (PAE) and objective meconium alcohol markers to determine the optimal meconium marker and threshold for identifying PAE. Methods: Meconium fatty acid ethyl esters (FAEE), ethyl glucuronide (EtG), and ethyl sulfate (EtS) were quantified by liquid chromatography-tandem mass spectrometry in 0.1 g meconium from infants of Safe Passage Study participants. Detailed PAE information was collected from women with a vali...
Published on Dec 1, 2014in BMC Pregnancy and Childbirth 2.41
Shannon Lange14
Estimated H-index: 14
(U of T: University of Toronto),
Kevin D. Shield25
Estimated H-index: 25
(U of T: University of Toronto)
+ 2 AuthorsSvetlana Popova34
Estimated H-index: 34
Background Maternal self-reports, used for the detection of prenatal alcohol exposure (PAE), may lack validity, necessitating the use of an objective biomarker. The detection of fatty acid ethyl esters (products of non-oxidative ethanol metabolism) in meconium has been established as a novel biomarker of PAE. The purpose of the current study was to compare the prevalence of PAE as reported via maternal self-reports with the results of meconium testing, and to quantify the disparity between these...
Published on Jul 1, 2014in Pediatrics 5.40
Barbara R. Lucas10
Estimated H-index: 10
,
Jane Latimer44
Estimated H-index: 44
(USYD: University of Sydney)
+ 6 AuthorsElizabeth Elliott37
Estimated H-index: 37
(USYD: University of Sydney)
BACKGROUND AND OBJECTIVES: Gross motor (GM) deficits are often reported in children with prenatal alcohol exposure (PAE), but their prevalence and the domains affected are not clear. The objective of this review was to characterize GM impairment in children with a diagnosis of fetal alcohol spectrum disorder (FASD) or “moderate” to “heavy” maternal alcohol intake. METHODS: A systematic review with meta-analysis was conducted. Medline, Embase, Allied and Complementary Medicine Database, Cumulativ...
Published on Jun 23, 2014
Janet Bryanton11
Estimated H-index: 11
(UPEI: University of Prince Edward Island),
Joey Gareri16
Estimated H-index: 16
(U of T: University of Toronto)
+ 6 AuthorsKathy Bigsby1
Estimated H-index: 1
Alcohol use in pregnancy is one of the leading preventable causes of developmental delays and birth defects in children in North America. Fetal alcohol spectrum disorder (FASD) occurs in about 40% of children exposed to frequent/intensive gestational alcohol use. Fetal alcohol spectrum disorder is a “spectrum” disorder, and thus exhibits a wide range of manifestations, extending from major malformations and severe developmental delays to more subtle impairments that can severely affect a person’...
Published on Jan 1, 2014in Journal of Studies on Alcohol and Drugs 2.58
Manuela Pfinder4
Estimated H-index: 4
(Bielefeld University),
Anton E. Kunst71
Estimated H-index: 71
+ 2 AuthorsTanja G. M. Vrijkotte32
Estimated H-index: 32
Objective:Many women continue drinking alcohol during pregnancy. This study aimed to describe educational differences in continued drinking in early and late pregnancy and to examine the contribution of psychological and physical factors to the explanation of educational differences.Method:We examined 4,885 women enrolled in the Amsterdam Born Children and their Development study. Information on alcohol intake during pregnancy was based on self-reports at the 16th week of gestation and at 3 mont...
Published on Dec 2, 2013in PLOS ONE 2.78
Kaitlyn Delano3
Estimated H-index: 3
(U of T: University of Toronto),
Joey Gareri16
Estimated H-index: 16
(U of T: University of Toronto),
Gideon Koren83
Estimated H-index: 83
(UWO: University of Western Ontario)
Methadone maintenance treatment (MMT) is the standard of care during pregnancy for opioid-dependency, showing efficacy in improving prenatal care and reducing risk of relapse. By design, however, MMT is only intended to prevent withdrawal thus facilitating cognitive behavioural interventions. In order to maximize the benefits of MMT, it is essential that methadone is both properly prescribed and that additional addiction treatment is concurrently administered. This study aims to determine the ef...
Published on Dec 1, 2013in Drug and Alcohol Dependence 3.47
Philip A. May47
Estimated H-index: 47
(UNC: University of North Carolina at Chapel Hill),
Jason Blankenship11
Estimated H-index: 11
(UNM: University of New Mexico)
+ 15 AuthorsJulie M. Hasken10
Estimated H-index: 10
(UNC: University of North Carolina at Chapel Hill)
Background Concise, accurate measures of maternal prenatal alcohol use are needed to better understand fetal alcohol spectrum disorders (FASD).
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