Bhushan Kapur
University of Toronto
Publications 75
#1Kaitlyn Delano (U of T: University of Toronto)H-Index: 3
#2Gideon Koren (TAU: Tel Aviv University)H-Index: 86
Last.Bhushan Kapur (U of T: University of Toronto)H-Index: 21
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Our study aimed to estimate the prevalence of heavy fetal alcohol exposure through the analysis of meconium FAEEs as an objective biomarker of fetal exposure. We conducted a study on meconium samples collected nationwide through the Maternal-Infant Research on Environmental Chemicals (MIREC) Study Group. FAEE in meconium was quantified by an established headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry (SPME GC-MS). Out of 1315 samples collected in 10 Canadi...
1 CitationsSource
#2Amanda Carnevale (U of T: University of Toronto)H-Index: 5
Last.Darius J. BägliH-Index: 40
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Summary Background Polybrominated diphenyl ethers (PBDEs) are widely used flame retardants, and their endocrine-disrupting properties have focused growing attention regarding their teratogenic potential. We have recently documented that mothers of children born with hypospadias had been exposed to statistically higher levels of PBDE during pregnancy than mothers of healthy controls. However, it is not known which congeners of PBDE are associated with this putative teratogenic effect. Objectives ...
#1Shirley Poon (U of T: University of Toronto)H-Index: 2
#2Gideon Koren (UWO: University of Western Ontario)H-Index: 86
Last.Darius J. BägliH-Index: 40
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Importance Polybrominated diphenyl ethers (PBDEs) are added to many consumer products as flame retardants, and their endocrine-disrupting properties are a growing health concern in pregnancy. Objective To investigate whether in utero PBDE exposure as measured in maternal hair is associated with increased risk for hypospadias. Design, Setting, and Participants In this case-control study, the setting was the urology clinic of a tertiary pediatric hospital between January 3, 2011, and April 1, 2013...
4 CitationsSource
#1Shirley PoonH-Index: 4
#2Gideon KorenH-Index: 79
Last.Darius J. BägliH-Index: 40
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#1Meera RamaniH-Index: 3
Last.Peter L. Carlen (U of T: University of Toronto)H-Index: 61
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Abstract Maternal alcohol consumption during gestation can cause serious injury to the fetus, and may result in a range of physiological and behavioral impairments, including increased seizure susceptibility, that are collectively termed fetal alcohol spectrum disorder (FASD). The cellular mechanisms underlying increased seizure susceptibility in FASD are not well understood, but could involve altered excitatory coupling of neuronal populations mediated by gap junction proteins. We utilized a mo...
3 CitationsSource
#1Michal KrawczykH-Index: 3
#2Meera RamaniH-Index: 3
Last.Peter L. Carlen (U of T: University of Toronto)H-Index: 61
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Prenatal alcohol exposure (PAE) can lead to long-lasting neurological alterations that may predispose individuals to seizures and neurobehavioral dysfunction. To date, there exists limited information regarding the underlying pathophysiological mechanisms. The hippocampal CA3 region generates excitatory population activity, called sharp waves (SPWs), that provide an ideal model to study perturbations in neuronal excitability at the network and cellular levels. In the present study, we utilized a...
8 CitationsSource
OBJECTIVES: To assess the percentage of women of childbearing age with suboptimal levels of folate for protecting against neural tube defects (<906 nM), and assess folate status among the elderly. METHODS: A total of 1,035 anonymous blood samples from a centralized clinical laboratory, with a catchment area across the Greater Toronto Area, were assessed for red blood cell (RBC) folate concentrations using a chemiluminescent immunoassay. Folate analysis was requested by physicians as part of clin...
2 CitationsSource
#1Alon Shrim (MUHC: McGill University Health Centre)H-Index: 11
#2Bhushan Kapur (U of T: University of Toronto)H-Index: 21
Last.Richard N Brown (MUHC: McGill University Health Centre)H-Index: 17
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Abstract Objective To assess factors associated with low Red Blood Cell folate (RBCf) levels in an obstetric population in a tertiary centre. Methods Cross-sectional study. Three hundred and fifty women completed a questionnaire detailing use of folic acid supplementation, and had their RBCf levels measured. Values ≥906 nmol/L were considered optimal. Factors associated with optimal RBCf were assessed, individually and in a logistic regression model. Results Median RBCf was 1282 nmol/L. Thirty-f...
3 CitationsSource
#1Mahvash Shere (U of T: University of Toronto)H-Index: 3
#2Priya Bapat (U of T: University of Toronto)H-Index: 7
Last.Gideon Koren (U of T: University of Toronto)H-Index: 86
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Abstract Objective To conduct a systematic review evaluating the effectiveness of a folate-fortified oral contraceptive preparation in increasing blood folate concentrations to levels providing optimal protection against neural tube defects (> 906 nmol/L). Methods We searched Medline, EMBASE, Web of Science, and the Cochrane Library for human studies published from inception to June 2013 that evaluated oral contraceptive use and folate status. Case–control studies, cohort studies, and clinical t...
7 CitationsSource