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Bhushan Kapur
University of Toronto
77Publications
21H-index
1,670Citations
Publications 77
Newest
Published on Feb 19, 2019in Scientific Reports 4.01
Kaitlyn Delano3
Estimated H-index: 3
(U of T: University of Toronto),
Gideon Koren83
Estimated H-index: 83
(TAU: Tel Aviv University)
+ 1 AuthorsBhushan Kapur21
Estimated H-index: 21
(U of T: University of Toronto)
Our study aimed to estimate the prevalence of heavy fetal alcohol exposure through the analysis of meconium FAEEs as an objective biomarker of fetal exposure. We conducted a study on meconium samples collected nationwide through the Maternal-Infant Research on Environmental Chemicals (MIREC) Study Group. FAEE in meconium was quantified by an established headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry (SPME GC-MS). Out of 1315 samples collected in 10 Canadi...
Published on Jun 1, 2019in Journal of Pediatric Urology 1.74
G. Koren , Amanda Carnevale5
Estimated H-index: 5
(U of T: University of Toronto)
+ 3 AuthorsDarius J. Bägli38
Estimated H-index: 38
Summary Background Polybrominated diphenyl ethers (PBDEs) are widely used flame retardants, and their endocrine-disrupting properties have focused growing attention regarding their teratogenic potential. We have recently documented that mothers of children born with hypospadias had been exposed to statistically higher levels of PBDE during pregnancy than mothers of healthy controls. However, it is not known which congeners of PBDE are associated with this putative teratogenic effect. Objectives ...
Published on Sep 1, 2018in JAMA Pediatrics 12.00
Shirley Poon4
Estimated H-index: 4
(U of T: University of Toronto),
Gideon Koren83
Estimated H-index: 83
(UWO: University of Western Ontario)
+ 5 AuthorsDarius J. Bägli38
Estimated H-index: 38
Importance Polybrominated diphenyl ethers (PBDEs) are added to many consumer products as flame retardants, and their endocrine-disrupting properties are a growing health concern in pregnancy. Objective To investigate whether in utero PBDE exposure as measured in maternal hair is associated with increased risk for hypospadias. Design, Setting, and Participants In this case-control study, the setting was the urology clinic of a tertiary pediatric hospital between January 3, 2011, and April 1, 2013...
Published on Sep 1, 2018in Reproductive Toxicology 3.20
Shirley Poon4
Estimated H-index: 4
,
Gideon Koren80
Estimated H-index: 80
+ 5 AuthorsDarius J. Bägli38
Estimated H-index: 38
Published on Jul 1, 2016in Neurobiology of Disease 5.16
Meera Ramani3
Estimated H-index: 3
,
Shanthini Mylvaganam5
Estimated H-index: 5
+ 8 AuthorsGeorg Zoidl5
Estimated H-index: 5
(York University)
Abstract Maternal alcohol consumption during gestation can cause serious injury to the fetus, and may result in a range of physiological and behavioral impairments, including increased seizure susceptibility, that are collectively termed fetal alcohol spectrum disorder (FASD). The cellular mechanisms underlying increased seizure susceptibility in FASD are not well understood, but could involve altered excitatory coupling of neuronal populations mediated by gap junction proteins. We utilized a mo...
Published on Jun 1, 2016in Experimental Neurology 4.56
Michal Krawczyk2
Estimated H-index: 2
,
Meera Ramani3
Estimated H-index: 3
+ 8 AuthorsMichael O. Poulter13
Estimated H-index: 13
(UWO: University of Western Ontario)
Prenatal alcohol exposure (PAE) can lead to long-lasting neurological alterations that may predispose individuals to seizures and neurobehavioral dysfunction. To date, there exists limited information regarding the underlying pathophysiological mechanisms. The hippocampal CA3 region generates excitatory population activity, called sharp waves (SPWs), that provide an ideal model to study perturbations in neuronal excitability at the network and cellular levels. In the present study, we utilized a...
Mahvash Shere3
Estimated H-index: 3
,
Bhushan Kapur21
Estimated H-index: 21
,
Gideon Koren80
Estimated H-index: 80
OBJECTIVES: To assess the percentage of women of childbearing age with suboptimal levels of folate for protecting against neural tube defects (<906 nM), and assess folate status among the elderly. METHODS: A total of 1,035 anonymous blood samples from a centralized clinical laboratory, with a catchment area across the Greater Toronto Area, were assessed for red blood cell (RBC) folate concentrations using a chemiluminescent immunoassay. Folate analysis was requested by physicians as part of clin...
Published on Jun 1, 2015in Reproductive Toxicology 3.20
Alon Shrim3
Estimated H-index: 3
(MUHC: McGill University Health Centre),
Bhushan Kapur21
Estimated H-index: 21
(U of T: University of Toronto)
+ 3 AuthorsRichard Brown3
Estimated H-index: 3
(MUHC: McGill University Health Centre)
Abstract Objective To assess factors associated with low Red Blood Cell folate (RBCf) levels in an obstetric population in a tertiary centre. Methods Cross-sectional study. Three hundred and fifty women completed a questionnaire detailing use of folic acid supplementation, and had their RBCf levels measured. Values ≥906 nmol/L were considered optimal. Factors associated with optimal RBCf were assessed, individually and in a logistic regression model. Results Median RBCf was 1282 nmol/L. Thirty-f...
Mahvash Shere3
Estimated H-index: 3
(U of T: University of Toronto),
Priya Bapat7
Estimated H-index: 7
(U of T: University of Toronto)
+ 2 AuthorsGideon Koren83
Estimated H-index: 83
(U of T: University of Toronto)
Abstract Objective To conduct a systematic review evaluating the effectiveness of a folate-fortified oral contraceptive preparation in increasing blood folate concentrations to levels providing optimal protection against neural tube defects (> 906 nmol/L). Methods We searched Medline, EMBASE, Web of Science, and the Cochrane Library for human studies published from inception to June 2013 that evaluated oral contraceptive use and folate status. Case–control studies, cohort studies, and clinical t...
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