Original paper
Multiple kinesins induce tension for smooth cargo transport
Abstract
How cargoes move within a crowded cell—over long distances and at speeds nearly the same as when moving on unimpeded pathway—has long been mysterious. Through an in vitro force-gliding assay, which involves measuring nanometer displacement and piconewtons of force, we show that multiple mammalian kinesin-1 (from 2 to 8) communicate in a team by inducing tension (up to 4 pN) on the cargo. Kinesins adopt two distinct states, with one-third slowing...
Paper Details
Title
Multiple kinesins induce tension for smooth cargo transport
Published Date
Oct 31, 2019
Journal
Volume
8
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Notes
History