The Neuronal Tau Protein Blocks In Vitro Fibrillation of the Amyloid-β (Aβ) Peptide

Two pathophysiological characteristics in brains of Alzheimer's disease are accumulation of aggregated Amyloid-β (Aβ) peptides and hyperphosphorylated tau proteins as extracellular senile plaques and intracellular neurofibrillary tangles (NFTs), respectively. Both types of deposits develop both independently and with combined pathological reciprocal effects. The interplay between native full-length tau protein (tau-441) and Aβ40 from a molecular...