Sex hormones modulate pathogenic processes in experimental traumatic brain injury

Clinical and animal studies have revealed sex‐specific differences in histopathological and neurological outcome after traumatic brain injury ( TBI ). The impact of perioperative administration of sex steroid inhibitors on TBI is still elusive. Here, we subjected male and female C57Bl/6N mice to the controlled cortical impact ( CCI ) model of TBI and applied pharmacological inhibitors of steroid hormone synthesis, that is, letrozole ( LET ,...