Exploring the Sulfatase 1 Catch Bond Free Energy Landscape using Jarzynski's Equality

In non-covalent biological adhesion, molecular bonds commonly exhibit a monotonously decreasing lifetime when subjected to tensile forces (slip bonds). In contrast, catch bonds behave counter intuitively, as they show an increased lifetime within a certain force interval. To date only a hand full of catch bond displaying systems have been identified. In order to unveil their nature, a number of structural and phenomenological models have been...