The Binding Interactions that Maintain the Ec Coupling Junctions in Skeletal Muscle

Intracellular release of calcium for contraction of skeletal muscles requires RyR1 channels of the sarcoplasmic reticulum, SR, assembled as orthogonal arrays in couplons, at junctions where the SR abuts either T tubules or the plasmalemma. Within couplons, CaV1.1 belonging to T tubules or plasmalemma associate with each of the four protomers of the tetrameric RyR forming symmetric complexes called tetrads. However, tetrads regularly skip every...