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Clara Franzini-Armstrong
University of Pennsylvania
AnatomyRyanodine receptorEndoplasmic reticulumSkeletal muscleBiology
249Publications
64H-index
12.9kCitations
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Publications 250
Newest
#1Manuela Lavorato (UPenn: University of Pennsylvania)H-Index: 5
#2Federico Formenti (University of Oxford)H-Index: 11
Last. Clara Franzini-Armstrong (UPenn: University of Pennsylvania)H-Index: 64
view all 3 authors...
NEW FINDINGS: What is the topic for this review? This review summarizes recent discoveries in mitochondrial development and morphology studied with electron microscopy. What advances does it highlight? Although mitochondria are generally considered to be isolated from each other, this review highlights recently discovered evidence for the presence of intermitochondrial communication structures in cardiac and skeletal muscle, in animal models and humans. Within striated muscles, the means of inte...
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Summary Mutations in VHL, which encodes von Hippel–Lindau tumor suppressor (VHL), are associated with divergent diseases. We describe a patient with marked erythrocytosis and prominent mitochondria...
3 CitationsSource
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#1Ramesh Iyer (Children's Hospital of Philadelphia)
#2Oliver Monfredi (Johns Hopkins University)H-Index: 15
Last. Clara Franzini-Armstrong (UPenn: University of Pennsylvania)H-Index: 64
view all 5 authors...
The main mammalian heart pacemakers are spindle-shaped cells compressed into tangles within protective layers of collagen in the sino-atrial node (SAN). Two cell types, "dark" and "light," differ on their high or low content of intermediate filaments, but share scarcity of myofibrils and a high content of glycogen. Sarcoplasmic reticulum (SR) is scarce. The free SR (fSR) occupies 0.04% of the cell volume within ~0.4 microm wide peripheral band. The junctional SR (jSR), constituting peripheral co...
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: Using a variety of technical approaches, we have detected the presence of continuous triads that cover the entire length of T tubules in the main white body muscles of several small fish. This is in contrast to the discontinuous association of sarcoplasmic reticulum with T tubules in the red muscles from the same fish as well as in all other previously described muscles in a large variety of skeletal muscles. We suggest that continuous triads are permissible only in muscle fibers that are not ...
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#1Eduardo Ríos (Rush University)H-Index: 52
#2Dirk Gillespie (Rush University)H-Index: 34
Last. Clara Franzini-Armstrong (UPenn: University of Pennsylvania)H-Index: 64
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Calcium for contraction of skeletal muscles is released via tetrameric ryanodine receptor (RYR1) channels of the sarcoplasmic reticulum (SR), which are assembled in ordered arrays called couplons at junctions where the SR abuts T tubules or plasmalemma. Voltage-gated Ca 2+ (Ca V 1.1) channels, found in tubules or plasmalemma, form symmetric complexes called Ca V tetrads that associate with and activate underlying RYR tetramers during membrane depolarization by conveying a conformational change. ...
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#1Eduardo RíosH-Index: 52
#2Dirk GillespieH-Index: 34
Last. Clara Franzini-ArmstrongH-Index: 64
view all 3 authors...
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#1Nosta Glaser (UPenn: University of Pennsylvania)
#2Ramesh Iyer (Children's Hospital of Philadelphia)
Last. Clara Franzini-Armstrong (UPenn: University of Pennsylvania)H-Index: 64
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: Muscles of the mesopelagic copepod Gaussia princeps (Arthropoda, Crustacea, Calanoida) are responsible for repetitive movements of feeding and swimming appendages that are too fast to be followed by eye. This article provides a comparative functional and ultrastructural description of five muscles that have different contraction speeds and are located within different anatomical sites. All are very fast, as indicated by a thick:thin filament ratio of 3:1 and sarcomere lengths that vary between...
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#1Manuela Lavorato (UPenn: University of Pennsylvania)H-Index: 5
#2Emanuele Loro (UPenn: University of Pennsylvania)H-Index: 16
Last. Clara Franzini-Armstrong (UPenn: University of Pennsylvania)H-Index: 64
view all 5 authors...
ABSTRACT Mitochondria respond to stress and undergo fusion and fission at variable rates, depending on cell status. To understand mitochondrial behavior during muscle fatigue, we investigated mitochondrial ultrastructure and expression levels of a fission- and stress-related protein in fast-twitch muscle fibers of mice subjected to fatigue testing. Mice were subjected to running at increasing speed until exhaustion at 45 min–1 h. In further experiments, high-intensity muscle stimulation through ...
1 CitationsSource
#1In-Gyun Lee (UPenn: University of Pennsylvania)H-Index: 1
#2Mara A. Olenick (UPenn: University of Pennsylvania)H-Index: 4
Last. Roberto Dominguez (UPenn: University of Pennsylvania)H-Index: 42
view all 6 authors...
Cytoplasmic dynein is the major minus-end-directed microtubule-based motor in cells. Dynein processivity and cargo selectivity depend on cargo-specific effectors that, while generally unrelated, share the ability to interact with dynein and dynactin to form processive dynein–dynactin-effector complexes. How this is achieved is poorly understood. Here, we identify a conserved region of the dynein Light Intermediate Chain 1 (LIC1) that mediates interactions with unrelated dynein–dynactin effectors...
15 CitationsSource
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