Structural Contributions to Hydrodynamic Size of Quantum Dots for In-Vivo Single Molecule Tracking

Quantum dots are fluorescent nanoparticles with desirable spectral properties for in-vivo single-molecule imaging. However typical formulations used for imaging proteins in cells are hydrodynamically much larger than the protein targets, so it is critical to assess the impact of steric effects deriving from hydrodynamic size. We analyze a new class of quantum dots that have been engineered for minimized size specifically for imaging receptors in...