Original paper
Identification of FDA-approved drugs targeting the Farnesoid X Receptor
Abstract
The farnesoid X receptor (FXR) belongs to the nuclear receptor family and is activated by bile acids. Multiple, chemically rather diverse, FXR agonists have been developed and several of these compounds are currently tested in clinical trials for NAFLD and cholestasis. Here, we investigated possible FXR-agonism or antagonism of existing FDA/EMA-approved drugs. By using our recently developed FRET-sensor, containing the ligand binding domain of...
Paper Details
Title
Identification of FDA-approved drugs targeting the Farnesoid X Receptor
Published Date
Feb 18, 2019
Journal
Volume
9
Issue
1
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Notes
History