Structure Modelling of CaV1.1 Reveals Functional Trans-Domain Interactions Involved in Voltage Sensing

Voltage-gated calcium channels (CaV) consist of four homologous but non-identical repeats (I, II, III, IV), each containing a separate voltage-sensing domain (VSD) arranged around the common channel pore. Within each VSD the positive gating charges (R1, R2, R3, R4) in the transmembrane helix S4 sequentially interact with negative counter-charges in helices S2 and S3 to support the movement of the gating charges across the electrical field of the...