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Yousra El Ghaleb
Voltage-dependent calcium channelGatingCav1.1Calcium channelBiology
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#2Marta CampiglioH-Index: 8
Last. Bernhard E. FlucherH-Index: 37
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ABSTRACTThe voltage-gated calcium channel CaV1.1a primarily functions as voltage-sensor in skeletal muscle excitation-contraction (EC) coupling. In embryonic muscle the splice variant CaV1.1e, which lacks exon 29, additionally function as a genuine L-type calcium channel. Because previous work in most laboratories used a CaV1.1 expression plasmid containing a single amino acid substitution (R165K) of a critical gating charge in the first voltage-sensing domain (VSD), we corrected this substituti...
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