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Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease
Abstract
Alzheimer disease (AD) is a major cause of age-related dementia. We do not fully understand AD aetiology and pathogenesis, but oxidative damage is a key component. The brain mostly uses glucose for energy, but in AD and amnestic mild cognitive impairment glucose metabolism is dramatically decreased, probably owing, at least in part, to oxidative damage to enzymes involved in glycolysis, the tricarboxylic acid cycle and ATP biosynthesis....
Paper Details
Title
Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease
Published Date
Feb 8, 2019
Journal
Volume
20
Issue
3
Pages
148 - 160
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