Pore-Blocking Effect of Isoindoline MDIMP on Voltage-Gated Calcium Channels

MDIMP is an isoindoline derived of leucine containing an ester group. molecular docking studies suggest that mdimp interacts with voltage-gated calcium channels (vgccs). In theory, the molecule binds to pore-leaning segments and interacts with one of the glutamates belonging to the selectivity filter (e736, located in domain ii of cav1.2). Accordingly, mdimp inhibits vgccs in cardiac myocytes, and the effect is more potent on low-threshold than...