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Guillermo Avila
CINVESTAV
Ryanodine receptorChemistryRYR1Skeletal muscleBiochemistry
39Publications
17H-index
1,062Citations
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Publications 38
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#1Guillermo AvilaH-Index: 17
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The skeletal muscle and myocardial cells present highly specialized structures; for example, the close interaction between the sarcoplasmic reticulum (SR) and mitochondria—responsible for excitation-metabolism coupling—and the junction that connects the SR with T-tubules, critical for excitation-contraction (EC) coupling. The mechanisms that underlie EC coupling in these two cell types, however, are fundamentally distinct. They involve the differential expression of Ca2+ channel subtypes: CaV1.1...
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#1Adrian Monsalvo-Villegas (CINVESTAV)H-Index: 1
#2Diana Stephanie Osornio-Garduño (CINVESTAV)H-Index: 2
Last. Guillermo Avila (CINVESTAV)H-Index: 17
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Pirfenidone (PFD) is used to treat human pulmonary fibrosis. Its administration to animals with distinct forms of cardiovascular disease results in striking improvement in cardiac performance. Here, its functional impact on cardiac myocytes was investigated. Cells were kept 1-2 d under either control culture conditions or the presence of PFD (1 mM). Subsequently, they were subjected to electrical stimulation to assess the levels of contractility and intracellular Ca2+. The PFD treatment promoted...
1 CitationsSource
#1Guillermo Avila (CINVESTAV)H-Index: 17
Ca2+ is essential for proper structure and function of skeletal muscle. It not only activates contraction and force development but also participates in multiple signaling pathways. Low levels of Ca2+ restrain muscle regeneration by limiting the fusion of satellite cells. Ironically, sustained elevations of Ca2+ also result in muscle degeneration as this ion promotes high rates of protein breakdown. Moreover, transforming growth factors (TGFs) which are well known for controlling muscle growth a...
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#1Maricela García-Castañeda (CINVESTAV)H-Index: 3
#2Ana Victoria Vega (UNAM: National Autonomous University of Mexico)H-Index: 2
Last. Guillermo Avila (CINVESTAV)H-Index: 17
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5 CitationsSource
#1Erick Benjamín Ríos-Pérez (CINVESTAV)H-Index: 2
#2Maricela García-Castañeda (CINVESTAV)H-Index: 3
Last. Guillermo Avila (CINVESTAV)H-Index: 17
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It is widely accepted that aldosterone induces atrial fibrillation (AF) by promoting structural changes, but its effects on the function of primary atrial myocytes remain unknown. We have investigated this point in adult rat atrial myocytes, chronically exposed to the hormone. This treatment produced larger amplitude of Ca2+ transients, longer action potential (AP) duration, and higher incidence of unsynchronized Ca2+ oscillations. Moreover, it also gave rise to increases in both cell membrane c...
1 CitationsSource
#1Mireille Aline Santamaria-Herrera (CINVESTAV)H-Index: 1
#2Erick Benjamín Ríos-Pérez (CINVESTAV)H-Index: 2
Last. Guillermo Avila (CINVESTAV)H-Index: 17
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Abstract In cardiac muscle cells both T-and L-type Ca 2+ channels (TTCCs and LTCCs, respectively) are expressed, and the latter are relevant to a process known as excitation-contraction coupling (ECC). Evidence obtained from docking studies suggests that isoindolines derived from α-amino acids bind to the LTCC Ca V 1.2. In the present study, we investigated whether methyl (S)-2-(1,3-dihydroisoindol-2-yl)-4-methylpentanoate (MDIMP), which is derived from L-leucine, modulates both Ca 2+ channels a...
4 CitationsSource
#1Erick Benjamín Ríos-Pérez (CINVESTAV)H-Index: 2
#2Maricela García-Castañeda (CINVESTAV)H-Index: 3
Last. Guillermo Avila (CINVESTAV)H-Index: 17
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In recent years, both aldosterone and mineralocorticoid receptor (MR) have drawn attention as important factors that promote structural remodeling of the atrium. Here, we investigated effects of chronic aldosterone treatment on both intracellular Ca2+ and ion channels. Atrial myocytes were cultured in either the absence or presence of aldosterone, and then the activity of ion channels was studied, under whole-cell patch-clamp conditions. Aldosterone increased both the cell membrane capacitance (...
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