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Guillermo Avila
CINVESTAV
39Publications
16H-index
1,040Citations
Publications 39
Newest
Published on Feb 1, 2019in Biophysical Journal3.67
María Guadalupe Montiel-Jaen1
Estimated H-index: 1
,
Adrián Monsalvo-Villegas1
Estimated H-index: 1
,
Guillermo Avila16
Estimated H-index: 16
Published on Feb 1, 2019in Biophysical Journal3.67
Juan Antonio Manuel de la Rosa1
Estimated H-index: 1
,
Maricela García-Castañeda3
Estimated H-index: 3
+ 3 AuthorsGuillermo Avila16
Estimated H-index: 16
Published on Dec 13, 2018in Frontiers in Physiology3.20
Adrián Monsalvo-Villegas1
Estimated H-index: 1
(CINVESTAV),
Diana Stephanie Osornio-Garduño2
Estimated H-index: 2
(CINVESTAV),
Guillermo Avila16
Estimated H-index: 16
(CINVESTAV)
Pirfenidone (PFD) is used to treat human pulmonary fibrosis. Its administration to animals with distinct forms of cardiovascular disease results in striking improvement in cardiac performance. Here, its functional impact on cardiac myocytes was investigated. Cells were kept 1-2 d under either control culture conditions or the presence of PFD (1 mM). Subsequently, they were subjected to electrical stimulation to assess the levels of contractility and intracellular Ca2+. The PFD treatment promoted...
Published on Jan 1, 2018
Guillermo Avila16
Estimated H-index: 16
(CINVESTAV)
Ca2+ is essential for proper structure and function of skeletal muscle. It not only activates contraction and force development but also participates in multiple signaling pathways. Low levels of Ca2+ restrain muscle regeneration by limiting the fusion of satellite cells. Ironically, sustained elevations of Ca2+ also result in muscle degeneration as this ion promotes high rates of protein breakdown. Moreover, transforming growth factors (TGFs) which are well known for controlling muscle growth a...
Published on Jul 1, 2017in The Journal of Physiology
Maricela García-Castañeda3
Estimated H-index: 3
(CINVESTAV),
Ana Victoria Vega7
Estimated H-index: 7
(UNAM: National Autonomous University of Mexico)
+ 4 AuthorsGuillermo Avila16
Estimated H-index: 16
(CINVESTAV)
Published on Nov 1, 2016in Pflügers Archiv: European Journal of Physiology3.38
Erick Benjamín Ríos-Pérez2
Estimated H-index: 2
(CINVESTAV),
Maricela García-Castañeda3
Estimated H-index: 3
(CINVESTAV)
+ 1 AuthorsGuillermo Avila16
Estimated H-index: 16
(CINVESTAV)
It is widely accepted that aldosterone induces atrial fibrillation (AF) by promoting structural changes, but its effects on the function of primary atrial myocytes remain unknown. We have investigated this point in adult rat atrial myocytes, chronically exposed to the hormone. This treatment produced larger amplitude of Ca2+ transients, longer action potential (AP) duration, and higher incidence of unsynchronized Ca2+ oscillations. Moreover, it also gave rise to increases in both cell membrane c...
Published on Jun 1, 2016in European Journal of Pharmacology3.17
Mireille Aline Santamaria-Herrera1
Estimated H-index: 1
(CINVESTAV),
Erick Benjamín Ríos-Pérez2
Estimated H-index: 2
(CINVESTAV)
+ 5 AuthorsGuillermo Avila16
Estimated H-index: 16
(CINVESTAV)
Abstract In cardiac muscle cells both T-and L-type Ca 2+ channels (TTCCs and LTCCs, respectively) are expressed, and the latter are relevant to a process known as excitation-contraction coupling (ECC). Evidence obtained from docking studies suggests that isoindolines derived from α-amino acids bind to the LTCC Ca V 1.2. In the present study, we investigated whether methyl (S)-2-(1,3-dihydroisoindol-2-yl)-4-methylpentanoate (MDIMP), which is derived from L-leucine, modulates both Ca 2+ channels a...
Published on Jan 1, 2015in Biophysical Journal3.67
Erick Benjamín Ríos-Pérez2
Estimated H-index: 2
(CINVESTAV),
Maricela García-Castañeda3
Estimated H-index: 3
(CINVESTAV),
Guillermo Avila16
Estimated H-index: 16
(CINVESTAV)
In recent years, both aldosterone and mineralocorticoid receptor (MR) have drawn attention as important factors that promote structural remodeling of the atrium. Here, we investigated effects of chronic aldosterone treatment on both intracellular Ca2+ and ion channels. Atrial myocytes were cultured in either the absence or presence of aldosterone, and then the activity of ion channels was studied, under whole-cell patch-clamp conditions. Aldosterone increased both the cell membrane capacitance (...
Published on Nov 1, 2014in Cell Calcium3.93
Guillermo Avila16
Estimated H-index: 16
(CINVESTAV),
Diana Stephanie Osornio-Garduño2
Estimated H-index: 2
(CINVESTAV)
+ 1 AuthorsRoberto Ramos-Mondragón6
Estimated H-index: 6
(CINVESTAV)
Abstract A synthetic compound, termed pirfenidone (PFD), is considered promising for the treatment of cardiac disease. It leads to beneficial effects in animal models of diabetes mellitus (DM); as well as in heart attack, atrial fibrillation, muscular dystrophy, and diabetic cardiomyopathy (DC). The latter is a result of alterations linked to metabolic syndrome as they promote cardiac hypertrophy, fibrosis and contractile dysfunction. Although reduced level of fibrosis and stiffness represent an...
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