Macrophage fatty acid oxidation inhibits atherosclerosis progression
Abstract
Atherosclerosis is a chronic disorder of the vessel wall. One key regulator of disease progression is lipid handling in macrophages. However, the role of macrophage mitochondrial-dependent fatty acid β-oxidation (FAO) in atherosclerosis is not well defined. To address this, we focused on carnitine palmitoyltransferase (CPT) 1 and 2, which play an essential role in the transport of long chain fatty acids (FAs) into the mitochondria. Using...
Paper Details
Title
Macrophage fatty acid oxidation inhibits atherosclerosis progression
Published Date
Feb 1, 2019
Volume
127
Pages
270 - 276
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