Toren Finkel
University of Pittsburgh
Molecular biologyMitochondrionBiochemistryBiologyCell biology
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Publications 247
#1Jay X. Tan (University of Pittsburgh)
#2Toren Finkel (University of Pittsburgh)H-Index: 87
Mitochondria, long viewed solely in the context of bioenergetics, are increasingly emerging as critical hubs for intracellular signaling. Due to their bacterial origin, mitochondria possess their own genome and carry unique lipid components that endow these organelles with specialized properties to help orchestrate multiple signaling cascades. Mitochondrial signaling modulates diverse pathways ranging from metabolism to redox homeostasis to cell fate determination. Here, we review recent progres...
#1Tamara Cruz (University of Pittsburgh)
#2Minxue Jia (University of Pittsburgh)
Last. Ana L. Mora (University of Pittsburgh)H-Index: 26
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#1Travis Lear (University of Pittsburgh)H-Index: 6
#2Karina C. Lockwood (University of Pittsburgh)
Last. Daniel J. Kass (University of Pittsburgh)H-Index: 13
view all 15 authors...
Systemic scleroderma (SSc) is an autoimmune disease that affects over 2.5 million people globally. SSc results in dysfunctional connective tissues with excessive pro-fibrotic signaling, affecting skin, cardiovascular, and particularly lung tissue. Over three-quarters of individuals with SSc develop pulmonary fibrosis within 5 years, the main cause of SSc mortality. No approved medicines to manage lung SSc currently exist. Recent research suggests that pro-fibrotic signaling by transforming growt...
#1Julia C. LiuH-Index: 4
Last. Sara MenazzaH-Index: 17
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The mitochondrial calcium uniporter is widely accepted as the primary route of rapid calcium entry into mitochondria, where increases in matrix calcium contribute to bioenergetics but also mitochondrial permeability and cell death. Hence, regulation of uniporter activity is critical to mitochondrial homeostasis. The uniporter subunit EMRE is known to be an essential regulator of the channel-forming protein MCU in cell culture, but EMRE's impact on organismal physiology is less understood. Here w...
1 CitationsSource
#1Ryan Houston (University of Pittsburgh)
#2Shiori Sekine (University of Pittsburgh)H-Index: 1
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The metabolite acetyl-CoA serves as an essential element for a wide range of cellular functions including ATP production, lipid synthesis and protein acetylation. Intracellular acetyl-CoA concentrations are associated with nutrient availability, but the mechanisms by which a cell responds to fluctuations in acetyl-CoA levels remain elusive. Here, we generate a cell system to selectively manipulate the nucleo-cytoplasmic levels of acetyl-CoA using CRISPR-mediated gene editing and acetate suppleme...
#1Shohini Ghosh-Choudhary (University of Pittsburgh)H-Index: 1
#2Jie Liu (University of Pittsburgh)H-Index: 2
Last. Toren Finkel (University of Pittsburgh)H-Index: 87
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Increasing evidence implicates metabolic pathways as key regulators of cell fate and function. Although the metabolism of glucose, amino acids, and fatty acids is essential to maintain overall energy homeostasis, the choice of a given metabolic pathway and the levels of particular substrates and intermediates increasingly appear to modulate specific cellular activities. This connection is likely related to the growing appreciation that molecules such as acetyl-CoA act as a shared currency betwee...
1 CitationsSource
#1Maria Paola Santini (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 2
#2Daniela Malide (NIH: National Institutes of Health)H-Index: 29
Last. Jason C. Kovacic (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 34
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Summary PDGFRα+ mesenchymal progenitor cells are associated with pathological fibro-adipogenic processes. Conversely, a beneficial role for these cells during homeostasis or in response to revascularization and regeneration stimuli is suggested, but remains to be defined. We studied the molecular profile and function of PDGFRα+ cells in order to understand the mechanisms underlying their role in fibrosis versus regeneration. We show that PDGFRα+ cells are essential for tissue revascularization a...
Toren Finkel lauds two books outlining very different ways of achieving a longer ‘healthspan’ — through pharmacology or integrative care. Toren Finkel lauds two books outlining very different ways of achieving a longer ‘healthspan’ — through pharmacology or integrative care.
#1Sai Prasad Pydi (NIH: National Institutes of Health)H-Index: 12
#2Shanu Jain (NIH: National Institutes of Health)H-Index: 2
Last. Jürgen Wess (NIH: National Institutes of Health)H-Index: 72
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β-Arrestins are major regulators of G protein-coupled receptor-mediated signaling processes. Their potential roles in regulating adipocyte function in vivo remain unexplored. Here we report the novel finding that mice lacking β-arrestin-2 (barr2) selectively in adipocytes show significantly reduced adiposity and striking metabolic improvements when consuming excess calories. We demonstrate that these beneficial metabolic effects are due to enhanced signaling through adipocyte β3-adrenergic recep...
1 CitationsSource
#1Young Yeon Kim (Dong-a University)H-Index: 3
#2Jee-Hyun Um (Dong-a University)H-Index: 4
Last. Jeanho Yun (Dong-a University)H-Index: 14
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Mitophagy has been implicated in mitochondrial quality control and in various human diseases. However, the study of in vivo mitophagy remains limited. We previously explored in vivo mitophagy using...
1 CitationsSource