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Toren Finkel
University of Pittsburgh
240Publications
86H-index
48.2kCitations
Publications 240
Newest
#1Sai P. Pydi (NIH: National Institutes of Health)
#2Shanu Jain (NIH: National Institutes of Health)H-Index: 1
Last.Jie LiuH-Index: 82
view all 10 authors...
β-Arrestins are major regulators of G protein-coupled receptor-mediated signaling processes. Their potential roles in regulating adipocyte function in vivo remain unexplored. Here we report the novel finding that mice lacking β-arrestin-2 (barr2) selectively in adipocytes show significantly reduced adiposity and striking metabolic improvements when consuming excess calories. We demonstrate that these beneficial metabolic effects are due to enhanced signaling through adipocyte β3-adrenergic recep...
#1Young Yeon Kim (Dong-a University)H-Index: 2
#2Jee-Hyun Um (Dong-a University)H-Index: 3
Last.Yoon-Gu Jang (SNU: Seoul National University)H-Index: 1
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Mitophagy has been implicated in mitochondrial quality control and in various human diseases. However, the study of in vivo mitophagy remains limited. We previously explored in vivo mitophagy using a transgenic mouse expressing the mitochondria-targeted fluorescent protein Keima (mt-Keima). Here, we generated mt-Keima Drosophila to extend our efforts to study mitophagy in vivo. A series of experiments confirmed that mitophagy can be faithfully and quantitatively measured in mt-Keima Drosophila. ...
Toren Finkel lauds two books outlining very different ways of achieving a longer ‘healthspan’ — through pharmacology or integrative care. Toren Finkel lauds two books outlining very different ways of achieving a longer ‘healthspan’ — through pharmacology or integrative care.
#1Haixin ZhaoH-Index: 2
#2Teng LiH-Index: 2
Last.Lin LiH-Index: 1
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The capacity of cells to alter bioenergetics in response to the demands of various biological processes is essential for normal physiology. The coordination of energy sensing and production with highly energy-demanding cellular processes, such as cell division, is poorly understood. Here, we show that a cell cycle-dependent mitochondrial Ca2+ transient connects energy sensing to mitochondrial activity for mitotic progression. The mitochondrial Ca2+ uniporter (MCU) mediates a rapid mitochondrial ...
#1Suman K. VodnalaH-Index: 11
#2Robert Eil (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 12
Last.Zhiya YuH-Index: 43
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INTRODUCTION Cancers persist and progress despite the presence of tumor-infiltrating lymphocytes (TILs). A paradox of tumor immunology is that tumor antigen–specific TILs are dysfunctional in situ and yet can mediate regression of large metastatic tumors after immune checkpoint blockade or adoptive cell transfer. TILs are predominantly considered “exhausted” because of chronic antigen exposure, but recent studies have revealed that T cells within tumors exist in a continuum of epigenetic, transc...
#1Mitsunori NomuraH-Index: 1
#2Jie Liu (University of Pittsburgh)H-Index: 2
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Abstract Atherosclerosis is a chronic disorder of the vessel wall. One key regulator of disease progression is lipid handling in macrophages. However, the role of macrophage mitochondrial-dependent fatty acid β-oxidation (FAO) in atherosclerosis is not well defined. To address this, we focused on carnitine palmitoyltransferase (CPT) 1 and 2, which play an essential role in the transport of long chain fatty acids (FAs) into the mitochondria. Using conditional alleles of these mitochondrial enzyme...
#1Randi J. Parks (NIH: National Institutes of Health)H-Index: 8
#2Sara Menazza (NIH: National Institutes of Health)H-Index: 17
Last.Elizabeth Murphy (NIH: National Institutes of Health)H-Index: 79
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#1Jason C. Kovacic (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 31
#2Stefanie Dimmeler (Goethe University Frankfurt)H-Index: 132
Last.Alison Baker (Edin.: University of Edinburgh)H-Index: 66
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Endothelial to mesenchymal transition (EndMT) is a process whereby an endothelial cell undergoes a series of molecular events that lead to a change in phenotype toward a mesenchymal cell (e.g., myofibroblast, smooth muscle cell). EndMT plays a fundamental role during development, and mounting evidence indicates that EndMT is involved in adult cardiovascular diseases (CVDs), including atherosclerosis, pulmonary hypertension, valvular disease, and fibroelastosis. Therefore, the targeting of EndMT ...
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