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Journal of Molecular and Cellular Cardiology
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#1Miles A. Tanner (MU: University of Missouri)H-Index: 15
#2Toby P. Thomas (MU: University of Missouri)
Last.Laurel A. Grisanti (MU: University of Missouri)H-Index: 1
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Abstract Cardiomyocyte survival and death contributes to many cardiac diseases. A common mechanism of cardiomyocyte death is through apoptosis however, numerous death receptors (DR) have been virtually unstudied in the context of cardiovascular disease. Previous studies have identified TNF-related apoptosis inducing ligand (TRAIL) and its receptor, DR5, as being altered in a chronic catecholamine administration model of heart failure, and suggest a role of non-canonical signaling in cardiomyocyt...
#1Carolina Jaquenod De Giusti (CONICET: National Scientific and Technical Research Council)H-Index: 1
#2P.G. Blanco (CONICET: National Scientific and Technical Research Council)H-Index: 7
Last.Bernardo V. Alvarez (CONICET: National Scientific and Technical Research Council)H-Index: 14
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Abstract Heart failure is the leading cause of death among diabetic people. Cellular and molecular entities leading to diabetic cardiomyopathy are, however, poorly understood. Coupling of cardiac carbonic anhydrase II (CAII) and Na+/H+ exchanger 1 (NHE1) to form a transport metabolon was analyzed in obese type 2 diabetic mice (ob−/−) and control heterozygous littermates (ob+/−). Echocardiography showed elevated systolic interventricular septum thickness and systolic posterior wall thickness in o...
#1Liping Meng (ZJU: Zhejiang University)H-Index: 2
#2Hui Lin (ZJU: Zhejiang University)H-Index: 1
Last.Jufang Chi (ZJU: Zhejiang University)H-Index: 4
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Abstract Aims Doxorubicin (DOX), a widely used powerful chemotherapeutic component for cancer treatment, can give rise to severe cardiotoxicity that limits its clinical use. Pyroptosis is characterized by proinflammation and has been defined as a new type of programmed cell death in recent years. However, whether the DOX-induced cardiotoxicity is related to pyroptosis, and if so, which genes are involved in this process is largely unknown. In this study, we sought to identify the effect of DOX o...
#1Sienna Wong (WSU: Wayne State University)
#2Han-Zhong Feng (WSU: Wayne State University)H-Index: 7
Last.J.-P. Jin (WSU: Wayne State University)H-Index: 35
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Abstract The C-terminal end segment of troponin subunit I (TnI) is a structure highly conserved among the three muscle type-specific isoforms and across vertebrate species. Partial deletion or point mutation in this segment impairs cardiac muscle relaxation. In the present study, we characterized the C-terminal 27 amino acid peptide of human cardiac TnI (HcTnI-C27) for its role in modulating muscle contractility. Biologically or chemically synthesized HcTnI-C27 peptide retains an epitope structu...
Abstract Background Cultured adult mouse and rat cardiomyocytes are the best and low-cost cell model for cardiac cellular physiology, pathology, drug toxicity screening, and intervention. The functions of mouse cardiomyocytes decline faster than rat cardiomyocytes in culture conditions. However, little is known about the difference of mitochondrial function between cultured mouse and rat myocytes. Methods and results A large number of adult mouse and rat cardiomyocytes were comparative isolated ...
Abstract Coronary heart disease (CHD) is a common heart disease and the leading cause of cardiovascular death. Apoptosis and autophagy are two forms of programmed cell deaths which participate in the pathogenesis, development and prognosis of CHD. They are activated by several different pathways respectively and can interact with each other through the Beclin 1-Bcl-2/Bcl-xL complex, mTOR, TRAIL, TNF-α, ER stress and nucleus p53 pathways. Excessive apoptosis can promote myocardial ischemia, ische...
#1Benoît Blomme (University of Liège)H-Index: 1
#2Christophe Deroanne (University of Liège)H-Index: 16
Last.Alain Colige (University of Liège)H-Index: 29
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Abstract The mitral valve is a complex multilayered structure populated by fibroblast-like cells, valvular interstitial cells (VIC) which are embedded in an extracellular matrix (ECM) scaffold and are submitted to the mechanical deformations affecting valve at each heartbeat, for an average of 40 million times per year. Myxomatous mitral valve (MMV) is the most frequent heart valve disease characterized by disruption of several valvular structures due to alterations of their ECM preventing the c...
#1Limei Zhao (UW: University of Washington)
#2Lihua Sun (UW: University of Washington)
Last.Haodong Xu (UW: University of Washington)H-Index: 2
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Abstract Increased nuclear β-catenin interacting with T-cell factor 4 (TCF4) affects the expression of target genes including SCN5A in ischemic heart disease, which is characterized by frequent ventricular tachycardia/fibrillation. A complex of β-catenin and TCF4 inhibits cardiac Na+ channel activity by reducing NaV1.5 expression through suppressing SCN5A promoter activity in HL-1 cardiomyocytes. LF3, a 4-thioureido-benzenesulfonamide derivative and an inhibitor of β-catenin/TCF4 interaction, ha...
#1Wei-Jan Chen (CGU: Chang Gung University)H-Index: 20
#2Shang-Hung Chang (CGU: Chang Gung University)H-Index: 13
Last.Yung-Hsin Yeh (CGU: Chang Gung University)H-Index: 10
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Abstract Atrial fibrillation (AF) is associated with oxidative stress and Ca2+-handling abnormalities in atrial myocytes. Our prior study has demonstrated the involvement of CD44, a membrane receptor for hyaluronan (HA), in the pathogenesis of AF. This study further evaluated whether CD44 and its related signaling mediate atrial tachycardia-induced oxidative stress and Ca2+-handling abnormalities. Tachypacing in atrium-derived myocytes (HL-1 cell line) induced the activation of CD44-related sign...
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