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Journal of Molecular and Cellular Cardiology
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5.05
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18945
Papers 18869
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#1Shuling Han (NU: Northwestern University)H-Index: 1
#2Shiyue Xu (UAB: University of Alabama at Birmingham)
Last.Gangjian Qin (UAB: University of Alabama at Birmingham)H-Index: 31
view all 19 authors...
Abstract Objective The role of Src-associated-in-mitosis-68-kDa (Sam68) in cardiovascular biology has not been studied. A recent report suggests that Sam68 promotes TNF-α–induced NF-κB activation in fibroblasts. Here we sought to dissect the molecular mechanism by which Sam68 regulates NF-κB signaling and its functional significance in vascular injury. Approach and results The endothelial denudation injury was induced in the carotid artery of Sam68-null (Sam68−/−) and WT mice. Sam68−/− mice disp...
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#1Peter J. Kilfoil (University of Louisville)H-Index: 6
#2Kalyan C. Chapalamadugu (USF: University of South Florida)H-Index: 8
Last.Matthew A. Nystoriak (University of Louisville)H-Index: 11
view all 11 authors...
Abstract Voltage-gated potassium (Kv) channels control myocardial repolarization. Pore-forming Kvα proteins associate with intracellular Kvβ subunits, which bind pyridine nucleotides with high affinity and differentially regulate channel trafficking, plasmalemmal localization and gating properties. Nevertheless, it is unclear how Kvβ subunits regulate myocardial K+ currents and repolarization. Here, we tested the hypothesis that Kvβ2 subunits regulate the expression of myocardial Kv channels and...
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#1Shan Gao (Tianjin University of Traditional Chinese Medicine)H-Index: 1
#2Lingyan Li (Tianjin University of Traditional Chinese Medicine)H-Index: 4
Last.Guanwei Fan (Tianjin University of Traditional Chinese Medicine)H-Index: 19
view all 7 authors...
Abstract Background Ventricular remodeling is a major pathological process of normal heart failure. With the aging of society, poor diet control, social, psychological and other risk factors in our country, the incidence of myocardial infarction and hypertension is reported to increase yearly. Many treatment methods have effectively delayed the occurrence of ventricular remodeling. However, in order to prevent and delay the occurrence and development of ventricular remodeling, the new treatment ...
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#1Chengming Fan (UAB: University of Alabama at Birmingham)H-Index: 2
#2Vladimir G. Fast (UAB: University of Alabama at Birmingham)H-Index: 29
Last.Jianyi Zhang (UAB: University of Alabama at Birmingham)H-Index: 41
view all 11 authors...
Abstract Background Cardiomyocytes that have been differentiated from CCND2-overexpressing human induced-pluripotent stem cells (hiPSC-CCND2OE CMs) can proliferate when transplanted into mouse hearts after myocardial infarction (MI). However, it is unknown whether remuscularization can replace the thin LV scar and if the large muscle graft can electrophysiologically synchronize to the recipient myocardium. Our objectives are to evaluate the structural and functional potential of hiPSC-CCND2OE CM...
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#1Martina Klevstig (Sahlgrenska University Hospital)H-Index: 6
#2Muhammad Arif (KTH: Royal Institute of Technology)H-Index: 4
Last.Jan Borén (Sahlgrenska University Hospital)H-Index: 64
view all 17 authors...
Abstract Aims The microsomal triglyceride transport protein (MTTP) is critical for assembly and secretion of apolipoprotein B (apoB)-containing lipoproteins and is most abundant in the liver and intestine. Surprisingly, MTTP is also expressed in the heart. Here we tested the functional relevance of cardiac MTTP expression. Materials and methods We combined clinical studies, advanced expression analysis of human heart biopsies and analyses in genetically modified mice lacking cardiac expression o...
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#1Hua-Jun Cao (Dalian Medical University)H-Index: 1
#2Jiao Fang (Dalian Medical University)
Last.Hui-Hua Li (Dalian Medical University)H-Index: 32
view all 11 authors...
Abstract Hypertensive cardiac remodeling is a major cause of heart failure. The immunoproteasome is an inducible form of the proteasome and its catalytic subunit β5i (also named LMP7) is involved in angiotensin II-induced atrial fibrillation; however, its role in deoxycorticosterone-acetate (DOCA)-salt-induced cardiac remodeling remains unclear. C57BL/6 J wild-type (WT) and β5i knockout (β5i KO) mice were subjected to uninephrectomy (sham) and DOCA-salt treatment for three weeks. Cardiac functio...
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#1Hui Gong (ZJU: Zhejiang University)H-Index: 1
#2Jiaojiao Ni (ZJU: Zhejiang University)
Last.Yuehai Ke (ZJU: Zhejiang University)H-Index: 21
view all 10 authors...
Abstract Mutations in the PTPN11 gene, which encodes the protein tyrosine phosphatase Shp2, cause Noonan syndrome and LEOPARD syndrome, inherited multifaceted diseases including cardiac and vascular defects. However, the function of Shp2 in blood vessels, especially in vascular smooth muscle cells (VSMCs), remains largely unknown. We generated mice in which Shp2 was specifically deleted in VSMCs and embryonic cardiomyocytes using the SM22α-Cre transgenic mouse line. Conditional Shp2 knockout res...
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#1Xingli Xu (MOE: Chinese Ministry of Education)H-Index: 2
#2Hong Jiang (MOE: Chinese Ministry of Education)H-Index: 11
Last.Yun Zhang (MOE: Chinese Ministry of Education)H-Index: 43
view all 9 authors...
Abstract Non-POU-domain-containing octamer-binding protein (NONO), a component of multifunctional Drosophila behavior/human splicing (DBHS) family, plays an important role in regulating glucose and fat metabolism, circadian cycles, cell division, collagen formation and fibrosis. Dysfunctional variants of NONO have been described as the cause of congenital heart defects in males. However, the effects of NONO deficiency on the ventricular function and cardiac fibrosis as well as the related mechan...
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#1Kai-Chien Yang (NTU: National Taiwan University)H-Index: 17
#2Kai-Wen Chuang (NTU: National Taiwan University)
Last.Show-Li Chen (NTU: National Taiwan University)H-Index: 18
view all 11 authors...
Abstract Background Cardiomyopathy is a common and lethal complication in patients with limb-girdle muscular dystrophy (LGMD), one of the most prevalent forms of muscular dystrophy. The pathogenesis underlying LGMD-related cardiomyopathy remains unclear. NRIP (gene name DCAF6), a Ca2+-dependent calmodulin binding protein, was reduced in dystrophic muscles from LGMD patients. Mice lacking NRIP exhibit a myopathic phenotype resembling that in LGMD patients, making NRIP deficiency a potential culpr...
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#1Anne Zwartsen (UU: Utrecht University)H-Index: 4
#2Tessa de Korte (LUMC: Leiden University Medical Center)H-Index: 2
Last.Laura Hondebrink (UU: Utrecht University)H-Index: 11
view all 6 authors...
Abstract The use of recreational drugs, including new psychoactive substances (NPS), is paralleled by emergency department visits of drug users with severe cardiotoxicity. Drug-induced cardiotoxicity can be the (secondary) result of increased norepinephrine blood concentrations, but data on potential drug-induced direct effects on cardiomyocyte function are scarce. The presence of hundreds of NPS therefore calls for efficient screening models to assess direct cardiotoxicity. We investigated effe...
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