Circulating histone H3 levels are increased in septic mice in a neutrophil-dependent manner: preclinical evaluation of a novel sandwich ELISA for histone H3

Published on Dec 1, 2018in Journal of intensive care
· DOI :10.1186/s40560-018-0348-y
Takashi Ito23
Estimated H-index: 23
(Kadai: Kagoshima University),
M Nakahara3
Estimated H-index: 3
(Kadai: Kagoshima University)
+ 7 AuthorsIkuro Maruyama38
Estimated H-index: 38
(Kadai: Kagoshima University)
Background Nuclear histone proteins are released into the extracellular space during sepsis and act as major mediators of death. However, circulating histone levels have not been precisely quantified.
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#1Gerben Marsman (UvA: University of Amsterdam)H-Index: 4
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#1Parjam S. Zolfaghari (UCL: University College London)H-Index: 4
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#1Masayuki Akatsuka (Sapporo Medical University)H-Index: 1
#2Yoshiki Masuda (Sapporo Medical University)H-Index: 12
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