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Takashi Ito
Kagoshima University
74Publications
23H-index
1,364Citations
Publications 73
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#1Kiyoaki Yamamoto (Kadai: Kagoshima University)H-Index: 2
#2Takashi Ito (Kadai: Kagoshima University)H-Index: 23
Last.Yoshihiko Nishio (Kadai: Kagoshima University)H-Index: 37
view all 11 authors...
Thrombus formation is an important factor affecting cardiovascular events and venous thromboembolism in type 2 diabetes. However, it is unclear whether glycemic control reduces thrombogenicity. We investigated the effect of short-term glycemic control (STUDY 1) and hypoglycemia (STUDY 2) on thrombus formation using an automated microchip flow chamber system. For STUDY 1, we recruited 10 patients with type 2 diabetes. Before and after 2 weeks of treatment, blood glucose was analyzed with a contin...
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#1Shotaro Miyamoto (Kadai: Kagoshima University)H-Index: 2
#2Takashi Ito (Kadai: Kagoshima University)H-Index: 23
Last.Yasuyuki Kakihana (Kadai: Kagoshima University)H-Index: 14
view all 8 authors...
Background Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral infectious disease with high mortality. It causes multiple organ dysfunction; however, myocarditis has never been reported as a complication with SFTS.
1 CitationsSource
#1Takashi Ito (Kadai: Kagoshima University)H-Index: 23
#2Jecko Thachil (University of Manchester)H-Index: 17
Last.Toshiaki Iba (Juntendo University)H-Index: 28
view all 5 authors...
Thrombomodulin plays a vital role in maintaining intravascular patency due to its anticoagulant, antiinflammatory, and cytoprotective properties. However, under pathological conditions such as sepsis and systemic inflammation, endothelial thrombomodulin expression is downregulated and its function impaired. As a result, administering thrombomodulin represents a potential therapeutic modality. Recently, the effect of recombinant thrombomodulin administration in sepsis-induced coagulopathy was eva...
1 CitationsSource
#1Yayoi Yokoyama (Kadai: Kagoshima University)H-Index: 1
#2Takashi Ito (Kadai: Kagoshima University)H-Index: 23
Last.Yasuyuki Kakihana (Kadai: Kagoshima University)H-Index: 14
view all 8 authors...
Background Nuclear histone proteins are released into the extracellular space, and act as major mediators of coagulopathy and remote organ failure in septic animals. However, the circulating histone levels in septic patients have not been precisely quantified.
1 CitationsSource
#1Binita Shrestha (UM: University of Michigan)
#2Takashi Ito (Kadai: Kagoshima University)H-Index: 23
Last.Ikuro Maruyama (Kadai: Kagoshima University)H-Index: 50
view all 7 authors...
Histones, the major protein components of chromatin, are released into the extracellular space during sepsis, trauma, and ischemia-reperfusion injury, and subsequently mediate organ failure. Extracellular histones can promote endothelial damage and platelet aggregation, which can be suppressed by administration of recombinant thrombomodulin (rTM). The present study aimed to clarify whether histones can activate neutrophils to induce NET formation and whether rTM can prevent histone-induced NET f...
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#1Kazuma YamakawaH-Index: 17
#2Jumpei YoshimuraH-Index: 4
Last.Satoshi FujimiH-Index: 9
view all 6 authors...
Background Two different criteria for evaluating coagulopathy in sepsis were recently released: sepsis-induced coagulopathy (SIC) and sepsis-associated coagulopathy (SAC). Although both use universal haemostatic markers of platelet count and pro-thrombin time, significance and usefulness of these criteria remain unclear. Objective This article validates and evaluates the significance of SIC and SAC criteria compared with the International Society on Thrombosis and Haemostasis (ISTH) overt dissem...
4 CitationsSource
#1Tomoaki YatabeH-Index: 15
#2Moritoki EgiH-Index: 10
Last.Masaji NishimuraH-Index: 24
view all 16 authors...
1 CitationsSource
#1Takashi Ito (Kadai: Kagoshima University)H-Index: 23
#2M Nakahara (Kadai: Kagoshima University)H-Index: 3
Last.Ikuro Maruyama (Kadai: Kagoshima University)H-Index: 38
view all 10 authors...
Background Nuclear histone proteins are released into the extracellular space during sepsis and act as major mediators of death. However, circulating histone levels have not been precisely quantified.
2 CitationsSource
#1Kiyoshi KikuchiH-Index: 27
#2Kentaro Setoyama (Kadai: Kagoshima University)H-Index: 8
Last.Salunya Tancharoen (MU: Mahidol University)H-Index: 18
view all 20 authors...
Uric acid (UA) therapy may prevent early ischemic worsening after acute stroke in thrombolysis patients. The aim of this study was to examine the influence of UA on the thrombolytic efficacy of alteplase in human blood samples by measuring thrombolysis under flow conditions using a newly developed microchip-based flow-chamber assay. Human blood samples from healthy volunteers were exposed to UA, alteplase, or a combination of UA and alteplase. Whole blood and platelet-rich plasma were perfused o...
1 CitationsSource
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