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M Nakahara
Kagoshima University
17Publications
3H-index
150Citations
Publications 17
Newest
#1Takashi Ito (Kadai: Kagoshima University)H-Index: 23
#2M Nakahara (Kadai: Kagoshima University)H-Index: 3
Last.Ikuro Maruyama (Kadai: Kagoshima University)H-Index: 38
view all 10 authors...
Background Nuclear histone proteins are released into the extracellular space during sepsis and act as major mediators of death. However, circulating histone levels have not been precisely quantified.
2 CitationsSource
#1Yasuyuki Kakihana (Kadai: Kagoshima University)H-Index: 14
#2Takashi Ito (Kadai: Kagoshima University)H-Index: 23
Last.Tomotsugu Yasuda (Kadai: Kagoshima University)H-Index: 14
view all 5 authors...
Sepsis is aggravated by an inappropriate immune response to invading microorganisms, which occasionally leads to multiple organ failure. Several lines of evidence suggest that the ventricular myocardium is depressed during sepsis with features of diastolic dysfunction. Potential candidates responsible for septic cardiomyopathy include pathogen-associated molecular patterns (PAMPs), cytokines, and nitric oxide. Extracellular histones and high-mobility group box 1 that function as endogenous damag...
69 CitationsSource
#1Tomotsugu Yasuda (Kadai: Kagoshima University)H-Index: 14
#2Keiji Yamaguchi (Kadai: Kagoshima University)H-Index: 2
Last.Yasuyuki Kakihana (Kadai: Kagoshima University)H-Index: 14
view all 14 authors...
The aim of the present study was to investigate whether changes in hepatic oxygenation can be detected by time-resolved spectroscopy (TRS) placed on the skin surface above the liver. METHODS: With approval of the local Hospital Ethics Committee and informed consent, six healthy volunteers aged 28.8 (25–36) years, and five patients with chronic renal failure aged 70.6 (58–81) years were studied. In six healthy volunteers, following echography, TRS (TRS-10, Hamamatsu Photonics K.K., Hamamatsu, Jap...
1 CitationsSource
#1Maiko Hasegawa-Moriyama (Kadai: Kagoshima University)H-Index: 6
#2M Nakahara (Kadai: Kagoshima University)H-Index: 3
Last.Yuichi Kanmura (Kadai: Kagoshima University)H-Index: 12
view all 8 authors...
Background: General anesthesia using remifentanil may suppress the unwanted metabolic changes caused by surgical stress including hyperglycemia and ketogenesis. Surgery-related changes in catabolism can be attenuated with low-dose glucose load, without causing hyperglycemia. However, the impact of glucose load in diabetic patients during surgery is unknown. In this study, we investigated the effect of glucose load on catabolism during remifentanil-based anesthesia in patients with diabetes melli...
1 CitationsSource
#1Tomotsugu Yamada (Kadai: Kagoshima University)H-Index: 3
#2Maiko Hasegawa-Moriyama (Kadai: Kagoshima University)H-Index: 6
Last.Yuichi Kanmura (Kadai: Kagoshima University)H-Index: 12
view all 5 authors...
Background: Perioperative exacerbation of hyperglycemia and insulin resistance is associated with increased complications in patients with diabetes mellitus. We recently reported that glucose load during anesthesia with sevoflurane suppressed lipid catabolism in diabetic patients. In contrast to inhaled anesthetics, propofol solution contains triglycerides, which can be an energy source during surgery. However, the clinical relevance of glucose load under propofol-based anesthesia in diabetic pa...
Source
#1Y Tomotsugu (Kadai: Kagoshima University)
#2Yasuyuki Kakihana (Kadai: Kagoshima University)H-Index: 14
Last.Naoko Okayama (Kadai: Kagoshima University)H-Index: 5
view all 8 authors...
The aim of the present study was to investigate whether the changes in hepatic oxygenation can be detected by time-resolved spectroscopy (TRS) placed on the skin surface above the liver.
Source
#1M NakaharaH-Index: 3
#2Takashi ItoH-Index: 23
Last.Ikuro MaruyamaH-Index: 50
view all 16 authors...
Source
#1M Nakahara (Kadai: Kagoshima University)H-Index: 3
#2Takashi Ito (Kadai: Kagoshima University)H-Index: 23
Last.Ikuro Maruyama (Kadai: Kagoshima University)H-Index: 38
view all 16 authors...
Introduction Recent studies have shown that histones, the chief protein component of chromatin, are released into the extracellular space during sepsis, trauma, and ischemia-reperfusion injury, and act as major mediators of the death of an organism. This study was designed to elucidate the cellular and molecular basis of histone-induced lethality and to assess the protective effects of recombinant thrombomodulin (rTM). rTM has been approved for the treatment of disseminated intravascular coagula...
70 CitationsSource
#1M NakaharaH-Index: 3
#2Tomotsugu YasudaH-Index: 14
Last.Yuichi KanmuraH-Index: 25
view all 6 authors...
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