Original paper
High fat diet increases cognitive decline and neuroinflammation in a model of orexin loss
Abstract
Midlife obesity is a risk factor for cognitive decline and is associated with the earlier onset of Alzheimer's disease (AD). Diets high in saturated fat potentiate the onset of obesity, microglial activation, and neuroinflammation. Signaling deficiencies in the hypothalamic peptide orexin and/or orexin fiber loss are linked to neurodegeneration, cognitive impairment, and neuroinflammation. Prior studies show that orexin is neuroprotective,...
Paper Details
Title
High fat diet increases cognitive decline and neuroinflammation in a model of orexin loss
Published Date
Jan 1, 2019
Volume
157
Pages
41 - 47
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Notes
History