Caspase‐1‐dependent mechanism mediating the harmful impacts of the quorum‐sensing molecule N‐(3‐oxo‐dodecanoyl)‐l‐homoserine lactone on the intestinal cells

Volume: 234, Issue: 4, Pages: 3621 - 3633
Published: Nov 23, 2018
Abstract
N‐(3‐oxododecanoyl)‐ l ‐homoserine lactone (3‐oxo‐C12‐HSL), a quorum‐sensing (QS) molecule produced by Gram‐negative bacteria in the gastrointestinal tract, adversly impacts host cells. Our previous study demonstrated that 3‐oxo‐C12‐HSL induced a decrease in cell viability via cell apoptosis and eventually disrupted mucin synthesis from LS174T goblet cells. However, the molecular mechanism underlying cell apoptosis and whether pyroptosis was...
Paper Details
Title
Caspase‐1‐dependent mechanism mediating the harmful impacts of the quorum‐sensing molecule N‐(3‐oxo‐dodecanoyl)‐l‐homoserine lactone on the intestinal cells
Published Date
Nov 23, 2018
Volume
234
Issue
4
Pages
3621 - 3633
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