Sodium‐glucose cotransporter 2 inhibitors regulate ketone body metabolism via inter‐organ crosstalk

Aim To investigate sodium‐glucose cotransporter 2 inhibitor (SGLT2i)‐induced changes in ketogenic enzymes and transporters in normal and diabetic mice models. Materials and methods Normal mice were randomly assigned to receive either vehicle or SGLT2i (25 mg/kg/d by oral gavage) for 7 days. Diabetic mice were treated with vehicle, insulin (4.5 units/kg/d by subcutaneous injection) or SGLT2i (25 mg/kg/d by intra‐peritoneal injection) for 5 weeks....