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Yong-ho Lee
Yonsei University
EndocrinologyType 2 diabetesType 2 Diabetes MellitusDiabetes mellitusMedicine
233Publications
27H-index
2,671Citations
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Publications 237
Newest
#1Da Hea Seo (IIT: Inha University)H-Index: 3
#2Yong-ho Lee (Yonsei University)H-Index: 27
Last. So Hun Kim (IIT: Inha University)H-Index: 14
view all 10 authors...
Abstract Background and aims Sarcopenia leads to metabolic and vascular abnormalities. However, little is known regarding the independent relationship between skeletal muscle mass and atherosclerosis in patients with type 2 diabetes mellitus (T2DM). This study aimed to evaluate the association between skeletal muscle mass and carotid atherosclerosis in men and women with T2DM. Methods In this cross-sectional study, a total of 8202 patients with T2DM were recruited from the Seoul Metabolic Syndro...
Source
#1Eun Ah Kim (Yonsei University)H-Index: 1
#2Jeong Gu Kang (Korea Research Institute of Bioscience and Biotechnology)
Last. Yung-soo Kim (Yonsei University)H-Index: 12
view all 14 authors...
The Hippo pathway controls organ size and tissue homeostasis by regulating cell proliferation and apoptosis. The LATS-mediated negative feedback loop prevents excessive activation of the effectors YAP/TAZ, maintaining homeostasis of the Hippo pathway. YAP and TAZ are hyperactivated in various cancer cells which lead to tumor growth. Aberrantly increased O-GlcNAcylation has recently emerged as a cause of hyperactivation of YAP in cancer cells. However, the mechanism, which induces hyperactivation...
Source
#1H. C. Lee (Yonsei University)H-Index: 4
#2Yongin Cho (IIT: Inha University)
Last. Yong-ho Lee (Yonsei University)H-Index: 27
view all 11 authors...
BACKGROUND There is increasing concern regarding cardiovascular risk in individuals with non-alcoholic fatty liver disease. This study was conducted to evaluate whether hepatic steatosis with or without fibrosis is associated with the progression of carotid atherosclerosis in patients with type 2 diabetes. METHODS From a longitudinal cohort, we enrolled 1120 patients with type 2 diabetes who underwent repeated carotid artery ultrasonography every 1-2 years. Ultrasonographic findings at baseline ...
2 CitationsSource
#1Sergio GhioneH-Index: 26
#1Ele FerranniniH-Index: 75
Last. Peter Ganz (UCSF: University of California, San Francisco)H-Index: 86
view all 9 authors...
OBJECTIVE To assess the effects of empagliflozin, a selective sodium–glucose cotransporter 2 (SGLT2) inhibitor, on broad biological systems through proteomics. RESEARCH DESIGN AND METHODS Aptamer-based proteomics was used to quantify 3,713 proteins in 144 paired plasma samples obtained from 72 participants across the spectrum of glucose tolerance before and after 4 weeks of empagliflozin 25 mg/day. The biology of the plasma proteins significantly changed by empagliflozin (at false discovery rate...
Source
#1Da Hea SeoH-Index: 3
#2Yongin ChoH-Index: 7
Last. So Hun KimH-Index: 14
view all 9 authors...
Background: Recent studies investigated the association between nonalcoholic fatty liver disease (NAFLD) and diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM) but the results are inconclusive. Here we aimed to investigate the effect of obesity on the association between NAFLD and DKD in a large cohort of participants with T2DM. Methods: In this cross-sectional study, a total of 3,439 patients (1,710 men and 1,729 women) with T2DM were recruited from the Seoul Metabol...
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#1Byung Wan Lee (Yonsei University)
#1Byung-Wan Lee (Yonsei University)H-Index: 27
Last. Bong Soo Cha (Yonsei University)H-Index: 38
view all 11 authors...
: This clinical practice position statement, a product of the Fatty Liver Research Group of the Korean Diabetes Association, proposes recommendations for the diagnosis, progression and/or severity assessment, management, and follow-up of non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM). Patients with both T2DM and NAFLD have an increased risk of non-alcoholic steatohepatitis (NASH) and fibrosis and a higher risk of cardiovascular diseases and diabetic co...
Source
#1Hokyou Lee (Yonsei University)H-Index: 5
#2Gyuri Kim (SMC: Samsung Medical Center)H-Index: 12
Last. Yong-ho Lee (Yonsei University)H-Index: 27
view all 3 authors...
Source
#1So Ra Kim (Yonsei University)H-Index: 6
#2Sang-Guk Lee (Yonsei University)H-Index: 14
Last. Min-Young Lee (Yonsei University)H-Index: 9
view all 22 authors...
Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce cardiovascular events in humans with type 2 diabetes (T2D); however, the underlying mechanism remains unclear. Activation of the NLR family, pyrin domain-containing 3 (NLRP3) inflammasome and subsequent interleukin (IL)-1β release induces atherosclerosis and heart failure. Here we show the effect of SGLT2 inhibitor empagliflozin on NLRP3 inflammasome activity. Patients with T2D and high cardiovascular risk receive SGLT2 inhibitor or sulfon...
4 CitationsSource
#1Eugene Han (KMU: Keimyung University)H-Index: 9
#2Ji-Yeon Lee (Yonsei University)H-Index: 12
Last. Yong-ho LeeH-Index: 27
view all 10 authors...
Diabetes is associated with cognitive impairment and greater risk for dementia, but the role of gamma-glutamyltransferase (γ-GT) in dementia has not been elucidated. We determined incident dementia including Alzheimer’s disease and vascular dementia, analyzing data from participants aged 40 years or older in the National Health Insurance Database, collected by the National Health Insurance Service in Korea, from January 2009 to December 2015. During a median follow-up of 7.6 years, 272,657 parti...
Source
#1Eugene Han (KMU: Keimyung University)H-Index: 9
#2Yong-ho Lee (Yonsei University)H-Index: 27
Last. Bong Soo Cha (Yonsei University)H-Index: 38
view all 14 authors...
OBJECTIVES: Nonalcoholic fatty liver disease (NAFLD) and sarcopenia have a close association with an increased risk of atherosclerotic cardiovascular disease (ASCVD). This study investigated the influence of NAFLD and sarcopenia on ASCVD risk. METHODS: Data from the 2008-2011 Korean National Health and Nutrition Examination Surveys database were analyzed (n = 7,191). The sarcopenia index was calculated using dual-energy x-ray absorptiometry. Sarcopenia was defined as the lowest quintile sarcopen...
1 CitationsSource
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