Original paper
Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1
Abstract
Interactions between the gut microbiota, diet, and the host potentially contribute to the development of metabolic diseases. Here, we identify imidazole propionate as a microbially produced histidine-derived metabolite that is present at higher concentrations in subjects with versus without type 2 diabetes. We show that imidazole propionate is produced from histidine in a gut simulator at higher concentrations when using fecal microbiota from...
Paper Details
Title
Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1
Published Date
Nov 1, 2018
Journal
Volume
175
Issue
4
Pages
947 - 961.e17
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Notes
History