Fredrik Bäckhed
University of Gothenburg
Publications 195
#2Al ReinbeckH-Index: 3
Last.Michael Roden (HHU: University of Düsseldorf)H-Index: 69
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#1Liisa Arike (University of Gothenburg)H-Index: 8
#2Andrus SeimanH-Index: 12
Last.Gunnar C. Hansson (University of Gothenburg)H-Index: 62
view all 9 authors...
Summary The gastrointestinal tract is covered by a single layer of epithelial cells that, together with the mucus layers, protect the underlying tissue from microbial invasion. The epithelium has one of the highest turnover rates in the body. Using stable isotope labeling, high-resolution mass spectrometry, and computational analysis, we report a comprehensive dataset of the turnover of more than 3,000 and the expression of more than 5,000 intestinal epithelial cell proteins, analyzed under conv...
#1Samer Al-Dury (University of Gothenburg)H-Index: 4
#2Annika Wahlström (University of Gothenburg)H-Index: 10
Last.Hanns-Ulrich Marschall (University of Gothenburg)H-Index: 52
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Abstract Background and aims The nuclear farnesoid X receptor (FXR) agonist obeticholic acid (OCA) has been developed for the treatment of liver diseases. We aimed to determine whether OCA treatment increases the risk of gallstone formation. Methods Twenty patients awaiting laparoscopic cholecystectomy were randomized to treatment with OCA (25 mg/day) or placebo for three weeks before surgery. Serum bile acids (BAs), the BA synthesis marker C4 (7α-hydroxy-cholest-4-ene-3-one), and fibroblast gro...
#1Lisa Olsson (University of Gothenburg)H-Index: 4
#2Christine PoitouH-Index: 36
Last.Robert Caesar (University of Gothenburg)H-Index: 16
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Objective The gut microbiota has been implicated in the aetiology of obesity and associated comorbidities. Patients with Prader-Willi syndrome (PWS) are obese but partly protected against insulin resistance. We hypothesised that the gut microbiota of PWS patients differs from that of non-genetically obese controls and correlate to metabolic health. Therefore, here we used PWS as a model to study the role of gut microbiota in the prevention of metabolic complications linked to obesity. Design We ...
#1D Djekic (Örebro University)
#2F Carlsson (SLU: Swedish University of Agricultural Sciences)
Last.Ole Fröbert (Örebro University)H-Index: 26
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#1Marcus FuldeH-Index: 19
#2Felix SommerH-Index: 16
Last.Mathias W. HornefH-Index: 12
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#1Jonna C. Sandberg (Lund University)H-Index: 5
#2Petia Kovatcheva-Datchary (University of Gothenburg)H-Index: 15
Last.Anne Nilsson (Lund University)H-Index: 17
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Purpose We previously showed that short-term intervention with barley kernel bread (BKB) improved glucose tolerance. However, glucose tolerance was not improved in a subset of individuals (non-responders) who were characterized by a low Prevotella/Bacteroides ratio. The purpose of the present study was to investigate if the baseline Prevotella/Bacteroides ratio can be used to stratify metabolic responders and non-responders to barley dietary fiber (DF).
8 CitationsSource
#1Angela Molinaro (University of Gothenburg)
#2Barbara Becattini (University of Gothenburg)H-Index: 13
Last.Giovanni Solinas (University of Gothenburg)H-Index: 21
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Summary Phosphatidylinositol-3-kinase (PI3K) activity is aberrant in tumors, and PI3K inhibitors are investigated as cancer therapeutics. PI3K signaling mediates insulin action in metabolism, but the role of PI3K isoforms in insulin signaling remains unresolved. Defining the role of PI3K isoforms in insulin signaling is necessary for a mechanistic understanding of insulin action and to develop PI3K inhibitors with optimal therapeutic index. We show that insulin-driven PI3K-AKT signaling depends ...
#1Pieter F. de Groot (UvA: University of Amsterdam)H-Index: 4
#2Torsten P.M. Scheithauer (UvA: University of Amsterdam)H-Index: 2
Last.Max NieuwdorpH-Index: 41
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Objective: Bariatric surgery improves glucose metabolism. Recent data suggest that faecal microbiota transplantation (FMT) using faeces from postbariatric surgery diet-induced obese mice in germ-free mice improves glucose metabolism and intestinal homeostasis. We here investigated whether allogenic FMT using faeces from post-Roux-en-Y gastric bypass donors (RYGB-D) compared with using faeces from metabolic syndrome donors (METS-D) has short-term effects on glucose metabolism, intestinal transit ...
2 CitationsSource
#1A. Molinaro (University of Gothenburg)H-Index: 5
#2Robert Caesar (University of Gothenburg)H-Index: 16
Last.Fredrik Bäckhed (UCPH: University of Copenhagen)H-Index: 75
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Abstract Objectives The nuclear receptor superfamily is a potential target for the development of new treatments for obesity and metabolic diseases. Increasing evidence has pointed towards the retinoic acid-related orphan receptor-alpha (RORα) as an important nuclear receptor involved in several biological processes. RORα full body knockout mice display improved metabolic phenotypes on both chow and high fat (60% fat, 20% carbohydrate) diets, but also have severe behavioral abnormalities. Here w...