P1‐173: BRAIN TRANSCRIPTOMICS STUDY REVEALS DIFFERENTIAL EXPRESSION OF THE THREE TREM2 TRANSCRIPT IN AD AND TREM2 MUTATION CARRIERS

CSF TREM2 protein levels are different between AD cases and controls and TREM2 risk variants have been associated with differential TREM2 protein levels in CSF and plasma, but no studies have been analyzed brain TREM2 expression levels. We wanted to determine whether there was a different expression of TREM2 in sporadic-AD cases vs Controls vs TREM2 carriers and if this is due to a particular TREM2 isoform. We analyzed RNA-Seq from brain tissue...