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Zeran Li
Washington University in St. Louis
14Publications
2H-index
41Citations
Publications 14
Newest
Jorge L. Del-Aguila8
Estimated H-index: 8
(WashU: Washington University in St. Louis),
Zeran Li2
Estimated H-index: 2
(WashU: Washington University in St. Louis)
+ -3 AuthorsKristy Bergmann (WashU: Washington University in St. Louis)
Alzheimer’s disease (AD) is the most common form of dementia. This neurodegenerative disorder is associated with neuronal death and gliosis heavily impacting the cerebral cortex. AD has a substantial but heterogeneous genetic component, presenting both Mendelian and complex genetic architectures. Using bulk RNA-seq from the parietal lobes and deconvolution methods, we previously reported that brains exhibiting different AD genetic architecture exhibit different cellular proportions. Here, we sou...
Published on Dec 1, 2019in Molecular Neurodegeneration8.27
Jorge L. Del-Aguila8
Estimated H-index: 8
(WashU: Washington University in St. Louis),
Bruno A. Benitez15
Estimated H-index: 15
(WashU: Washington University in St. Louis)
+ 12 AuthorsShan Jiang1
Estimated H-index: 1
(WashU: Washington University in St. Louis)
Background Low frequency coding variants in TREM2 are associated with Alzheimer disease (AD) risk and cerebrospinal fluid (CSF) TREM2 protein levels are different between AD cases and controls. Similarly, TREM2 risk variant carriers also exhibit differential CSF TREM2 levels. TREM2 has three different alternative transcripts, but most of the functional studies only model the longest transcript. No studies have analyzed TREM2 expression levels or alternative splicing in brains from AD and cogniti...
Yuetiva Deming8
Estimated H-index: 8
(UW: University of Wisconsin-Madison),
Fabia Filipello (WashU: Washington University in St. Louis)+ -3 AuthorsF. G. Farias (WashU: Washington University in St. Louis)
Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in cerebrospinal fluid (CSF) has been associated with Alzheimer’s disease (AD). TREM2 plays a critical role in microglial activation, survival, and phagocytosis; however, the pathophysiological role of sTREM2 in AD is not well understood. Understanding the role of sTREM2 in AD may reveal new pathological mechanisms and lead to the identification of therapeutic targets. We performed a genome-wide association study (GWAS) to identif...
Published on Mar 30, 2019in bioRxiv
Jorge L. Del-Aguila8
Estimated H-index: 8
(WashU: Washington University in St. Louis),
Zeran Li2
Estimated H-index: 2
(WashU: Washington University in St. Louis)
+ 15 AuthorsFengxian Wang (WashU: Washington University in St. Louis)
Alzheimer Disease (AD) is the most common form of dementia. This neurodegenerative disorder is associated with neuronal death and gliosis specifically in the cerebral cortex. AD has a substantial but heterogeneous genetic component, presenting both Mendelian and complex genetic architectures. We previously reported different cellular proportions between brains exhibiting different AD genetic architecture, that we identified using bulk RNA-seq from homogenized parietal lobes and deconvolution met...
Published on Mar 20, 2019in bioRxiv
Zeran Li2
Estimated H-index: 2
,
F. G. Farias + 17 AuthorsJohn Budde21
Estimated H-index: 21
(WashU: Washington University in St. Louis)
Background: In previous studies, we observed decreased neuronal and increased astrocyte proportions in AD cases in parietal brain cortex by using a deconvolution method for bulk RNA-seq. These findings suggested that genetic risk factors associated with AD etiology have a specific effect in the cellular composition of AD brains. The goal of this study is to investigate if there are genetic determinants for brain cell compositions. Methods: Using cell type composition inferred from transcriptome ...
Published on Dec 1, 2018in Genome Medicine10.89
Zeran Li2
Estimated H-index: 2
(WashU: Washington University in St. Louis),
Jorge L. Del-Aguila8
Estimated H-index: 8
(WashU: Washington University in St. Louis)
+ 12 AuthorsJin-Moo Lee41
Estimated H-index: 41
(WashU: Washington University in St. Louis)
Alzheimer’s disease (AD) is characterized by neuronal loss and astrocytosis in the cerebral cortex. However, the specific effects that pathological mutations and coding variants associated with AD have on the cellular composition of the brain are often ignored. We developed and optimized a cell-type-specific expression reference panel and employed digital deconvolution methods to determine brain cellular distribution in three independent transcriptomic studies. We found that neuronal and astrocy...
Published on Dec 1, 2018in Translational Psychiatry5.18
Shan Jiang1
Estimated H-index: 1
(WashU: Washington University in St. Louis),
Natalie Wen3
Estimated H-index: 3
(WashU: Washington University in St. Louis)
+ 10 AuthorsNigel J. Cairns77
Estimated H-index: 77
(WashU: Washington University in St. Louis)
Mutations in the microtubule-associated protein tau (MAPT) gene cause autosomal dominant frontotemporal lobar degeneration with tau inclusions (FTLD-tau). MAPT p.R406W carriers present clinically with progressive memory loss and neuropathologically with neuronal and glial tauopathy. However, the pathogenic events triggered by the expression of the mutant tau protein remain poorly understood. To identify the genes and pathways that are dysregulated in FTLD-tau, we performed transcriptomic analyse...
Published on Jul 3, 2018in Expert Opinion on Therapeutic Targets4.62
Yuetiva Deming8
Estimated H-index: 8
(WashU: Washington University in St. Louis),
Zeran Li2
Estimated H-index: 2
(WashU: Washington University in St. Louis)
+ 1 AuthorsCarlos Cruchaga48
Estimated H-index: 48
ABSTRACTIntroduction: There are currently no effective therapeutics for Alzheimer disease (AD). Clinical trials targeting amyloid beta thus far have shown very little benefit and only in the earliest stages of disease. These limitations have driven research to identify alternative therapeutic targets, one of the most promising is the triggering receptor expressed on myeloid cells 2 (TREM2).Areas covered: Here, we review the literature to-date and discuss the potentials and pitfalls for targeting...
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