Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure
Abstract
Pressure overload induces a transition from cardiac hypertrophy to heart failure, but its underlying mechanisms remain elusive. Here we reconstruct a trajectory of cardiomyocyte remodeling and clarify distinct cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure, by integrating single-cardiomyocyte transcriptome with cell morphology, epigenomic state and heart function. During early...
Paper Details
Title
Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure
Published Date
Oct 30, 2018
Journal
Volume
9
Issue
1
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