P1‐432: REGIONAL PATTERNS OF 18F‐FLORBETABEN UPTAKE IN PRESENILIN 1 MUTATION CARRIERS

Autosomal dominant Alzheimer's disease individuals show elevated 11C-Pittsburgh compound B (PiB) and 18-florbetapir uptake about 15 years before the estimated age of symptoms onset (EYO). It has not yet been established whether different amyloid tracers bind to identical sites on amyloid-β (Aβ) fibrils, offering the same ability to detect the regional Aβ burden. Regional disparities in fibrillar Aβ accumulation have also important implications...